Mechanistic insights into AMPK-SIRT3 positive feedback loop-mediated chondrocyte mitochondrial quality control in osteoarthritis pathogenesis: Osteoarthritis (OA) is a significant reason behind incapacity within the aged inhabitants and represents a big public well being downside and socioeconomic burden worldwide. Nonetheless, no disease-modifying therapeutics are at … Continue Reading →
Theaflavin protects chondrocytes against apoptosis and senescence via regulating Nrf2 and ameliorates murine osteoarthritis
Oxidative stress-mediated extreme apoptosis and senescence of chondrocytes are the primary pathological alterations within the osteoarthritis (OA) growth. The protecting results of theaflavin (TF), a standard group of polyphenols in … Continue Reading →
Novel copolymers drive differentiation of human adipose derived stem cells towards chondrocytes and osteoblasts identified by high-throughput approach
Human adipose derived stem cells (hASCs) have been seeded onto polymer microarrays that had been fabricated utilizing a wide range of acrylate monomers to find novel substrates that induced differentiation … Continue Reading →
Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1
Osteoarthritis is essentially the most prevalent joint degenerative illness and has been thought of a serious reason behind extreme joint ache and bodily incapacity within the aged. The chondrocyte is … Continue Reading →
Effect of Rubus idaeus Extracts in Murine Chondrocytes and Explants
Osteoarthritis is characterised by cartilage loss ensuing from the activation of chondrocytes related to a synovial irritation. Activated chondrocytes promote an elevated secretion of matrix proteases and proinflammatory cytokines resulting … Continue Reading →
Downregulation of IRAK3 by miR-33b-3p relieves chondrocyte inflammation and apoptosis in an in vitro osteoarthritis model
Interleukin-1 receptor-associated kinase-3 (IRAK3) has a particular position in regulating irritation. Nevertheless, the practical position of IRAK3 and regulatory mechanism underlying the pathogenesis of osteoarthritis (OA) stay unclear. Right here, … Continue Reading →
Mechanistic insights into AMPK-SIRT3 positive feedback loop-mediated chondrocyte mitochondrial quality control in osteoarthritis pathogenesis
Osteoarthritis (OA) is a significant reason behind incapacity within the aged inhabitants and represents a big public well being downside and socioeconomic burden worldwide. Nonetheless, no disease-modifying therapeutics are at … Continue Reading →