Osteoarthritis is characterised by cartilage loss ensuing from the activation of chondrocytes related to a synovial irritation. Activated chondrocytes promote an elevated secretion of matrix proteases and proinflammatory cytokines resulting in cartilage breakdown. Since pure merchandise possess anti-inflammatory properties, we investigated the direct impact of Rubus idaeus extracts (RIE) in chondrocyte metabolism and cartilage loss. The impact of RIE in chondrocyte metabolism was analyzed in murine main chondrocytes and cartilage explants.
We additionally assessed the contribution of RIE in an irritation surroundings by culturing mice main chondrocytes with the supernatant of Uncooked 264.7 macrophage-like cells primed with RIE. In main chondrocytes, RIE diminished chondrocyte hypertrophy (Col10), whereas growing the expression of catabolic genes (Mmp-3, Mmp-13) and decreasing anabolic genes (Col2a1, Acan).
In cartilage explants, Rubus idaeus prevented the lack of proteoglycan (14.84 ± 3.07% lack of proteoglycans with IL1 alone vs. 3.03 ± 1.86% with IL1 and 100 µg/mL of RIE), in addition to the NITEGE neoepitope expression. RIE alone lowered the expression of Il1 and Il6 in macrophages, with out adjustments in Tnf and Cox2 expression. The secretome of macrophages pre-treated with RIE and transferred to chondrocytes decreases the gene and protein expression of Mmp-3 and Cox2. In conclusion, these knowledge counsel that RIE could defend from chondrocyte catabolism and cartilage loss in inflammatory circumstances. Additional evaluations are want earlier than contemplating RIE as a candidate for the therapy for osteoarthritis.
AKAP2 overexpression modulates progress plate chondrocyte capabilities by way of ERK1/2 signaling
In our earlier examine, the mutation c.2645A > C (p. E882A) was discovered within the A-Kinase Anchoring Protein 2 (AKAP2) gene, which performs an vital position in regulating the event of the skeletal system; nonetheless, the precise impact of AKAP2 on chondrocyte proliferation and differentiation and the potential mechanism are nonetheless not clear. Within the current examine, we investigated the impact of AKAP2 in vitro. We efficiently remoted human progress plate chondrocytes (GPCs) from progress plate cartilage tissues and recognized GPCs by aggrecan expression and movement cytometric evaluation.
AKAP2 overexpression considerably promoted GPC proliferation, enhanced GPC differentiation, and promoted extracellular matrix (ECM) synthesis, whereas AKAP2 silencing exerted the alternative results on GPCs. AKAP2 overexpression elevated, whereas AKAP2 silencing decreased, the protein ranges of p-extracellular regulated protein kinases (ERK)1/2.
Extra importantly, the promotive results of AKAP2 overexpression on GPC proliferation, differentiation, and ECM synthesis have been considerably reversed by the ERK1/2 signaling antagonist U0126, suggesting that AKAP2 enhances GPC capabilities by way of ERK1/2 signaling. In conclusion, we reveal AKAP2 overexpression-induced enhancement of GPC capabilities by way of ERK1/2 signaling. Contemplating the important position of GPC capabilities in adolescent idiopathic scoliosis (AIS) pathogenesis, the appliance of AKAP2 concentrating on in AIS therapy must be investigated in future research.
Ameliorative Results of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Mannequin
Arthritis is a typical inflammatory illness that causes ache, stiffness, and joint swelling. Right here, we investigated the ameliorative results of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and remoted from Cornus officinalis (CO) extract to display for anti-arthritic results. A single element, loganin, was recognized as a candidate.
The CO extract and loganin inhibited the expression of things related to cartilage degradation, resembling cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte irritation. As well as, prostaglandin and collagenase ranges have been lowered following therapy of IL-1β-induced chondrocytes with loganin. Within the destabilization of the medial meniscus (DMM)-induced mouse mannequin, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT photos revealed that loganin lowered DMM-induced osteophyte formation. These outcomes point out that loganin has protecting results in DMM-induced mice.
SIRT1 immediately prompts autophagy in human chondrocytes
Osteoarthritis (OA) is the most typical type of arthritis worldwide with no efficient therapy. Ageing is the first threat issue for OA. We sought to research if there’s a distinct and useful convergence of ageing-related mechanisms SIRT1 and autophagy in chondrocytes. Our outcomes present that, ranges of SIRT1 are decreased in human regular aged and OA cartilage in contrast with younger cartilage.
Furthermore, silencing SIRT1 in chondrocytes result in decreased expression of chondrogenic markers however didn’t alter the expression of catabolic proteases. In distinction, activation of SIRT1 elevated autophagy in chondrocytes by the deacetylation of lysine residues on essential autophagy proteins (Beclin1, ATG5, ATG7, LC3). This activation was proven to be mTOR/ULK1 impartial. Our outcomes point out that upkeep of autophagy in chondrocytes by SIRT1 is important for preserving cartilage integrity all through life and due to this fact is a goal for drug intervention to guard in opposition to OA.
Molecular and Mobile Results of Chemical Chaperone-TUDCA on ER-Burdened NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Circumstances
Osteoarthritis (OA) is taken into account some of the frequent arthritic illnesses characterised by progressive degradation and irregular reworking of articular cartilage. Potential therapeutics for OA purpose at restoring correct chondrocyte functioning and inhibiting apoptosis. Earlier research have demonstrated that tauroursodeoxycholic acid (TUDCA) confirmed anti-inflammatory and anti-apoptotic exercise in lots of fashions of varied illnesses, appearing primarily by way of alleviation of endoplasmic reticulum (ER) stress. Nonetheless, little is thought about cytoprotective results of TUDCA on chondrocyte cells.
The current examine was designed to judge potential results of TUDCA on interleukin-1β (IL-1β) and tunicamycin (TNC)-stimulated NHAC-kn chondrocytes cultured in normoxic and hypoxic circumstances. Our outcomes confirmed that TUDCA alleviated ER stress in TNC-treated chondrocytes, as demonstrated by lowered CHOP expression; nonetheless, it was not efficient sufficient to stop apoptosis of NHAC-kn cells in both normoxia nor hypoxia.
 Cellufine A-500 |
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| 19805 | JNC America | 500 ml | EUR 526 |
Cellufine A-500 |
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| 19806 | JNC America | 5 lt | Ask for price |
Cellufine A-500 |
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| 675980327 | JNC America | 100 ml | EUR 324 |
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| 21-500-15 | JNC America | 1 x 5 ml | EUR 451 |
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| 19865 | JNC America | 500 ml | EUR 526 |
Cellufine C-500 |
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| 675982327 | JNC America | 100 ml | EUR 366 |
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| 675983327 | JNC America | 100 ml | EUR 324 |
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 MC Cellufine Sulfate |
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| 19-845-15 | JNC America | 1 x 5 ml | EUR 366 |
MC Cellufine Sulfate |
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| 19-845-51 | JNC America | 5 x 1 ml | EUR 366 |
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| 195-15 | JNC America | 1 x 5 ml | EUR 430 |
MC Cellufine Phosphate |
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| 195-51 | JNC America | 5 x 1 ml | EUR 430 |
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| 202-15 | JNC America | 1 x 5 ml | EUR 452 |
MC Cellufine PB |
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| 202-51 | JNC America | 5 x 1 ml | EUR 452 |
 MC Cellufine MAX Q-r |
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| 20-500-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX Q-r |
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| 19-711-55 | JNC America | 5 x 5 ml | EUR 430 |
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| 20-700-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX Phenyl |
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| 20-700-55 | JNC America | 5 x 5 ml | EUR 537 |
 MC Cellufine MAX CM |
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| 20-900 | JNC America | 100 ml | EUR 382 |
MC Cellufine MAX CM |
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| 20-900-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX CM |
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| 20-900-55 | JNC America | 5 x 5 ml | EUR 526 |
MC Cellufine MAX CM |
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| 20-901 | JNC America | 500 ml | EUR 1464 |
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| 20-902 | JNC America | 5 lt | Ask for price |
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 MC Cellufine Etclean L |
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| 200-15 | JNC America | 1 x 5 ml | EUR 356 |
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| 200-51 | JNC America | 5 x 1 ml | EUR 356 |
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| 201-15 | JNC America | 1 x 5 ml | EUR 356 |
MC Cellufine Etclean S |
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| 201-51 | JNC America | 5 x 1 ml | EUR 356 |
 MC Cellufine MAX DEAE |
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| 21-000-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX DEAE |
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| 21-000-55 | JNC America | 5 x 5 ml | EUR 526 |
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| 21-100-51 | JNC America | 5 x 1 ml | EUR 271 |
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| 21-100-55 | JNC America | 5 x 5 ml | EUR 537 |
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| 21-300-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX GS |
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| 21-300-55 | JNC America | 5 x 5 ml | EUR 526 |
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| 21-600-15 | JNC America | 1 x 5 ml | EUR 302 |
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| 21-600-51 | JNC America | 5 x 1 ml | EUR 302 |
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| 21-900-11 | JNC America | 1 x 1 ml | EUR 372 |
MC Cellufine SPA-HC |
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| 21-900-15 | JNC America | 1 x 5 ml | EUR 553 |
MC Cellufine SPA-HC |
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| 21-900-51 | JNC America | 5 x 1 ml | EUR 553 |
 MC Cellufine MAX S-r |
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| 20-300-51 | JNC America | 5 x 1 ml | EUR 271 |
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| 20-400-55 | JNC America | 5 x 5 ml | EUR 526 |
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| 20-600-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX Q-h |
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| 20-600-55 | JNC America | 5 x 5 ml | EUR 526 |
 MC Cellufine MAX Phenyl LS |
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| 20-800-51 | JNC America | 5 x 1 ml | EUR 271 |
MC Cellufine MAX Phenyl LS |
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| 20-800-55 | JNC America | 5 x 5 ml | EUR 537 |
MC Cellufine MAX S-r |
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| 20300-55 | JNC America | 5 x 5 ml | EUR 526 |
 MC Cellufine MAX DexS-Vir |
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| 21-800-15 | JNC America | 1 x 5 ml | EUR 302 |
MC Cellufine MAX DexS-Vir |
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| 21-800-51 | JNC America | 5 x 1 ml | EUR 302 |
 Cellufine A-200 |
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| 19611 | JNC America | 500 ml | EUR 526 |
Cellufine A-200 |
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| 19612 | JNC America | 5 lt | Ask for price |
 Cellufine A-800 |
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| 19800 | JNC America | 500 ml | EUR 526 |
Cellufine A-800 |
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| 19801 | JNC America | 5 lt | Ask for price |
Cellufine A-800 |
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| 673980327 | JNC America | 100 ml | EUR 324 |
Cellufine A-800 |
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| 673980335 | JNC America | 10 lt | Ask for price |
Cellufine A-200 |
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| 676-980-327 | JNC America | 100 ml | EUR 324 |
Cellufine A-200 |
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| 676980335 | JNC America | 10 lt | Ask for price |
 A Medium |
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| DJ1018 | Bio Basic | 100g | EUR 84.8 |
 Cellufine MAX AminoButyl |
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| 21-500 | JNC America | 50 ml | EUR 375 |
 A-1 MEDIUM |
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| A01-116-10kg | Alphabiosciences | 10 kg | EUR 1034 |
A-1 MEDIUM |
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| A01-116-2Kg | Alphabiosciences | 2 Kg | EUR 264 |
A-1 MEDIUM |
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| A01-116-500g | Alphabiosciences | 500 g | EUR 108 |
 Cellufine MAX Q-r |
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| 20-500 | JNC America | 100 ml | EUR 382 |
 500 ML PF MEDIUM WITHOUT L-GLUTAMINE |
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| 40-200-CV | CORNING | 500 mL/pk | EUR 125 |
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Description: Specialty Media; Serum Free and Specialty Media |
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 Heller's Medium |
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| CP014-500 | GenDepot | 50L | EUR 126 |
 Hoagland's Medium |
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| CP015-500 | GenDepot | 50L | EUR 126 |
 Cellufine Phosphate |
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| 19-524 | JNC America | 10 ml | EUR 430 |
Cellufine Phosphate |
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| 19-545 | JNC America | 50 ml | EUR 452 |
Cellufine Phosphate |
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| 19-546 | JNC America | 500 ml | EUR 3372 |
 Cellufine Formyl |
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| 19-853 | JNC America | 50 ml | EUR 537 |
 Cellufine Sulfate |
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| 19845 | JNC America | 50 ml | EUR 558 |
Cellufine Sulfate |
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| 19846 | JNC America | 500 ml | EUR 2892 |
Cellufine Sulfate |
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| 19847 | JNC America | 5 lt | Ask for price |
Cellufine Sulfate |
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| 19849 | JNC America | 10 lt | Ask for price |
Cellufine Formyl |
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| 20-854 | JNC America | 500 ml | EUR 4075 |
Cellufine Formyl |
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| 21-855 | JNC America | 5 lt | Ask for price |
Cellufine Sulfate |
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| 676-943-324 | JNC America | 10 ml | EUR 302 |
Cellufine Formyl |
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| 676-944-324 | JNC America | 10 ml | EUR 324 |
Cellufine Formyl |
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| 676-944-335 | JNC America | 10 lt | Ask for price |
 Cellufine PB |
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| 683-986-324 | JNC America | 10 ml | EUR 452 |
Cellufine PB |
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| 683-986-326 | JNC America | 50 ml | Ask for price |
Cellufine PB |
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Cellufine PB |
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| 683-986-330 | JNC America | 5 lt | Ask for price |
Cellufine PB |
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| 683-986-335 | JNC America | 10 lt | Ask for price |
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| 684-987-335 | JNC America | 10 lt | Ask for price |
Cellufine Phosphate |
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| 685-987-330 | JNC America | 5 lt | Ask for price |
 Sepadextran-25 Medium |
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| SD25M-500 | ABTBeads | 500 g | EUR 1036 |
 Sepadextran-50 Medium |
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| SD50M-500 | ABTBeads | 500 g | EUR 1285 |
 Kao Michayluk Medium |
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| CP017-500 | GenDepot | 50L | EUR 126 |
 Orchid Maintenance Medium |
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| CP037-500 | GenDepot | 50L | EUR 138 |
 Woody Plants Medium |
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| CP040-500 | GenDepot | 50L | EUR 126 |
 500 ML HAM'S F-10 MEDIUM WITH L-GLUTAMINE |
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| 10-070-CV | CORNING | 500 mL/pk | EUR 71 |
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Description: Media Catalog; Classical Media |
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 500 ML HAM'S F-12 MEDIUM WITH L-GLUTAMINE |
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| 10-080-CV | CORNING | 500 mL/pk | EUR 64 |
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Description: Media Catalog; Classical Media |
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 FRIIS BASE Medium, Liquid |
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| F2485-500 | GenDepot | 500ml | Ask for price |
 Chu's N-6 Medium |
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| CP004-500 | GenDepot | 50L | EUR 126 |
 Gamborg's B-5 Medium |
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| CP009-500 | GenDepot | 50L | EUR 126 |
 Hoagland's Medium; Without Nitrogen |
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| CP016-500 | GenDepot | 50L | EUR 126 |
 Knudson C Orchid Medium |
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| CP041-500 | GenDepot | 50L | EUR 138 |
 500 BlotBot Reagent Reservoirs |
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| RRVR-500 | Next Advance | 500pack | EUR 534 |
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Description: BlotBot reagent reservoirs will allow dispensing of unique reagents tray during processing. Pack of 500. |
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 AlbuVoid Buffer Kit - 500 |
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| AVBK-500 | Biotech Support Group | 500 mL | EUR 615 |
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Description: Albuvoid™ Buffer |
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 HemoVoid Buffer Kit - 500 |
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| HVBK-500 | Biotech Support Group | 500 mL | EUR 615 |
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Description: HemoVoid™ Buffer |
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 UPCK Buffer Kit - 500 |
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| UPBK-500 | Biotech Support Group | 500 mL | EUR 615 |
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Description: UPCK™ Buffer |
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 Monoclonal Antibody [33D3]) 5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] |
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| A-1014 | EpiGentek | 100 µg | EUR 601 |
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Description: kits suitable for this type of research |
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 Cellufine GH-25 |
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| 19711 | JNC America | 500 ml | EUR 452 |
Cellufine GH-25 |
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| 19712 | JNC America | 5 lt | Ask for price |
 Cellufine MAX Phenyl |
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| 20700 | JNC America | 100 ml | EUR 366 |
Cellufine MAX Phenyl |
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| 20701 | JNC America | 500 ml | EUR 995 |
Cellufine MAX Phenyl |
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| 20702 | JNC America | 5 lt | Ask for price |
Cellufine MAX Phenyl |
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| 20703 | JNC America | 10 lt | Ask for price |
 Cellufine MAX DEAE |
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| 21-000 | JNC America | 100 ml | EUR 382 |
Cellufine MAX DEAE |
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| 21-001 | JNC America | 500 ml | EUR 1464 |
Cellufine MAX DEAE |
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| 21-002 | JNC America | 5 lt | Ask for price |
Cellufine MAX DEAE |
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| 21-003 | JNC America | 10 lt | Ask for price |
 Cellufine MAX Butyl |
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| 21-100 | JNC America | 100 ml | EUR 366 |
Cellufine MAX Butyl |
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| 21-101 | JNC America | 500 ml | EUR 995 |
Cellufine MAX Butyl |
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| 21-102 | JNC America | 5 lt | Ask for price |
Cellufine MAX Butyl |
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| 21-103 | JNC America | 10 lt | Ask for price |
 Cellufine MAX GS |
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| 21-300 | JNC America | 100 ml | EUR 505 |
Cellufine MAX GS |
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| 21-301 | JNC America | 500 ml | EUR 1635 |
Cellufine MAX GS |
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| 21-302 | JNC America | 5 lt | Ask for price |
Cellufine MAX GS |
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| 21-303 | JNC America | 10 lt | Ask for price |
 Cellufine GCL-2000HF |
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| 21-400 | JNC America | 100 ml | EUR 302 |
Cellufine GCL-2000HF |
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| 21-401 | JNC America | 500 ml | EUR 452 |
Cellufine GCL-2000HF |
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| 21-402 | JNC America | 5 lt | Ask for price |
Cellufine GCL-2000HF |
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| 21-403 | JNC America | 10 lt | Ask for price |
Cellufine MAX AminoButyl |
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| 21-501 | JNC America | 100 ml | EUR 622 |
Cellufine MAX AminoButyl |
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| 21-502 | JNC America | 500 ml | EUR 2466 |
Cellufine MAX AminoButyl |
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| 21-503 | JNC America | 5 lt | Ask for price |
Cellufine MAX AminoButyl |
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| 21-504 | JNC America | 10 lt | Ask for price |
 Cellufine MAX IB |
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| 21-600 | JNC America | 10 ml | EUR 260 |
Cellufine MAX IB |
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| 21-601 | JNC America | 50 ml | EUR 484 |
Cellufine MAX IB |
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| 21-602 | JNC America | 100 ml | EUR 628 |
Cellufine MAX IB |
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| 21-603 | JNC America | 500 ml | EUR 2402 |
Cellufine MAX IB |
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| 21-604 | JNC America | 5 lt | Ask for price |
Cellufine MAX IB |
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 Cellufine SPA-HC |
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| 21-900 | JNC America | 10 ml | EUR 686 |
Cellufine SPA-HC |
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| 21-901 | JNC America | 50 ml | EUR 1363 |
Cellufine SPA-HC |
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| 21-902 | JNC America | 500 ml | EUR 6857 |
Cellufine SPA-HC |
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| 21-903 | JNC America | 5 lt | Ask for price |
Cellufine SPA-HC |
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| 21-904 | JNC America | 10 lt | Ask for price |
Cellufine GH-25 |
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| 670000327 | JNC America | 100 ml | EUR 302 |
Cellufine GH-25 |
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| 670000335 | JNC America | 10 lt | Ask for price |
 Cellufine ETclean L |
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| 681-984-324 | JNC America | 10 ml | EUR 366 |
Cellufine ETclean L |
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| 681-984-326 | JNC America | 50 ml | EUR 590 |
Cellufine ETclean L |
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| 681-984-328 | JNC America | 500 ml | EUR 3020 |
Cellufine ETclean L |
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| 681-984-330 | JNC America | 5 lt | Ask for price |
Cellufine ETclean L |
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| 681-984-335 | JNC America | 10 lt | Ask for price |
 Cellufine ETclean S |
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| 682-985-324 | JNC America | 10 ml | EUR 366 |
Cellufine ETclean S |
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| 682-985-326 | JNC America | 50 ml | EUR 590 |
Cellufine ETclean S |
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| 682-985-328 | JNC America | 500 ml | EUR 3020 |
Cellufine ETclean S |
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| 682-985-330 | JNC America | 5 lt | Ask for price |
Cellufine ETclean S |
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| 682-985-335 | JNC America | 10 lt | Ask for price |
) Human Airway FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15001 | CHI Scientific | 1 Kit | Ask for price |
) Human Airway FibrOut2: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15002 | CHI Scientific | 1 Kit | Ask for price |
) Human Airway FibrOut3: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15003 | CHI Scientific | 1 Kit | Ask for price |
) Human Aorta FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15004 | CHI Scientific | 1 Kit | Ask for price |
) Human Artery FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15005 | CHI Scientific | 1 Kit | Ask for price |
) Human Bladder FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15006 | CHI Scientific | 1 Kit | Ask for price |
) Human Bladder FibrOut3: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15007 | CHI Scientific | 1 Kit | Ask for price |
) Human Bone FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15010 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut2: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15011 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut3: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15012 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut4: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15013 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut5: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15014 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut6: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15015 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut7: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15016 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut8: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15017 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut9: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15018 | CHI Scientific | 1 Kit | Ask for price |
) Human Brain FibrOut10: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15019 | CHI Scientific | 1 Kit | Ask for price |
) Human Breast FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15020 | CHI Scientific | 1 Kit | Ask for price |
) Human Cartilage FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15038 | CHI Scientific | 1 Kit | Ask for price |
) Human Cervix FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15039 | CHI Scientific | 1 Kit | Ask for price |
) Human Cervix FibrOut3: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15041 | CHI Scientific | 1 Kit | Ask for price |
) Human Cervix FibrOut4: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15042 | CHI Scientific | 1 Kit | Ask for price |
) Human Embryo FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15045 | CHI Scientific | 1 Kit | Ask for price |
) Human Embryo FibrOut3: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15047 | CHI Scientific | 1 Kit | Ask for price |
) Human Embryo FibrOut4: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15048 | CHI Scientific | 1 Kit | Ask for price |
) Human Endothelium FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15049 | CHI Scientific | 1 Kit | Ask for price |
) Human Esophagus FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15050 | CHI Scientific | 1 Kit | Ask for price |
) Human Esophagus FibrOut2: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15051 | CHI Scientific | 1 Kit | Ask for price |
) Human Eye FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15052 | CHI Scientific | 1 Kit | Ask for price |
) Human Eye FibrOut2: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15053 | CHI Scientific | 1 Kit | Ask for price |
) Human Eye FibrOut4: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15055 | CHI Scientific | 1 Kit | Ask for price |
) Human Eye FibrOut5: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15056 | CHI Scientific | 1 Kit | Ask for price |
) Human Fat FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15057 | CHI Scientific | 1 Kit | Ask for price |
Nonetheless, co-treatment with TUDCA alleviated inflammatory response induced by IL-1β, as proven by down regulation of Il-1β, Il-6, Il-8 and Cox2, and elevated the expression of antioxidant enzyme Sod2. Moreover, TUDCA enhanced Col IIα expression in IL-1β- and TNC-stimulated cells, however solely in normoxic circumstances. Altogether, these outcomes counsel that though TUDCA could show chondoprotective potential in ER-stressed cells, additional analyses are nonetheless crucial to totally affirm its attainable advice as potential candidate in OA remedy.
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