Effect of Rubus idaeus Extracts in Murine Chondrocytes and Explants

Osteoarthritis is characterised by cartilage loss ensuing from the activation of chondrocytes related to a synovial irritation. Activated chondrocytes promote an elevated secretion of matrix proteases and proinflammatory cytokines resulting in cartilage breakdown. Since pure merchandise possess anti-inflammatory properties, we investigated the direct impact of Rubus idaeus extracts (RIE) in chondrocyte metabolism and cartilage loss. The impact of RIE in chondrocyte metabolism was analyzed in murine main chondrocytes and cartilage explants.

We additionally assessed the contribution of RIE in an irritation surroundings by culturing mice main chondrocytes with the supernatant of Uncooked 264.7 macrophage-like cells primed with RIE. In main chondrocytes, RIE diminished chondrocyte hypertrophy (Col10), whereas growing the expression of catabolic genes (Mmp-3, Mmp-13) and decreasing anabolic genes (Col2a1, Acan).

In cartilage explants, Rubus idaeus prevented the lack of proteoglycan (14.84 ± 3.07% lack of proteoglycans with IL1 alone vs. 3.03 ± 1.86% with IL1 and 100 µg/mL of RIE), in addition to the NITEGE neoepitope expression. RIE alone lowered the expression of Il1 and Il6 in macrophages, with out adjustments in Tnf and Cox2 expression. The secretome of macrophages pre-treated with RIE and transferred to chondrocytes decreases the gene and protein expression of Mmp-3 and Cox2. In conclusion, these knowledge counsel that RIE could defend from chondrocyte catabolism and cartilage loss in inflammatory circumstances. Additional evaluations are want earlier than contemplating RIE as a candidate for the therapy for osteoarthritis.

AKAP2 overexpression modulates progress plate chondrocyte capabilities by way of ERK1/2 signaling

In our earlier examine, the mutation c.2645A > C (p. E882A) was discovered within the A-Kinase Anchoring Protein 2 (AKAP2) gene, which performs an vital position in regulating the event of the skeletal system; nonetheless, the precise impact of AKAP2 on chondrocyte proliferation and differentiation and the potential mechanism are nonetheless not clear. Within the current examine, we investigated the impact of AKAP2 in vitro. We efficiently remoted human progress plate chondrocytes (GPCs) from progress plate cartilage tissues and recognized GPCs by aggrecan expression and movement cytometric evaluation.

AKAP2 overexpression considerably promoted GPC proliferation, enhanced GPC differentiation, and promoted extracellular matrix (ECM) synthesis, whereas AKAP2 silencing exerted the alternative results on GPCs. AKAP2 overexpression elevated, whereas AKAP2 silencing decreased, the protein ranges of p-extracellular regulated protein kinases (ERK)1/2.

Extra importantly, the promotive results of AKAP2 overexpression on GPC proliferation, differentiation, and ECM synthesis have been considerably reversed by the ERK1/2 signaling antagonist U0126, suggesting that AKAP2 enhances GPC capabilities by way of ERK1/2 signaling. In conclusion, we reveal AKAP2 overexpression-induced enhancement of GPC capabilities by way of ERK1/2 signaling. Contemplating the important position of GPC capabilities in adolescent idiopathic scoliosis (AIS) pathogenesis, the appliance of AKAP2 concentrating on in AIS therapy must be investigated in future research.

Effect of Rubus idaeus Extracts in Murine Chondrocytes and Explants

Ameliorative Results of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Mannequin

Arthritis is a typical inflammatory illness that causes ache, stiffness, and joint swelling. Right here, we investigated the ameliorative results of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and remoted from Cornus officinalis (CO) extract to display for anti-arthritic results. A single element, loganin, was recognized as a candidate.
The CO extract and loganin inhibited the expression of things related to cartilage degradation, resembling cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte irritation. As well as, prostaglandin and collagenase ranges have been lowered following therapy of IL-1β-induced chondrocytes with loganin. Within the destabilization of the medial meniscus (DMM)-induced mouse mannequin, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT photos revealed that loganin lowered DMM-induced osteophyte formation. These outcomes point out that loganin has protecting results in DMM-induced mice.

SIRT1 immediately prompts autophagy in human chondrocytes

Osteoarthritis (OA) is the most typical type of arthritis worldwide with no efficient therapy. Ageing is the first threat issue for OA. We sought to research if there’s a distinct and useful convergence of ageing-related mechanisms SIRT1 and autophagy in chondrocytes. Our outcomes present that, ranges of SIRT1 are decreased in human regular aged and OA cartilage in contrast with younger cartilage.
Furthermore, silencing SIRT1 in chondrocytes result in decreased expression of chondrogenic markers however didn’t alter the expression of catabolic proteases. In distinction, activation of SIRT1 elevated autophagy in chondrocytes by the deacetylation of lysine residues on essential autophagy proteins (Beclin1, ATG5, ATG7, LC3). This activation was proven to be mTOR/ULK1 impartial. Our outcomes point out that upkeep of autophagy in chondrocytes by SIRT1 is important for preserving cartilage integrity all through life and due to this fact is a goal for drug intervention to guard in opposition to OA.

Molecular and Mobile Results of Chemical Chaperone-TUDCA on ER-Burdened NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Circumstances

Osteoarthritis (OA) is taken into account some of the frequent arthritic illnesses characterised by progressive degradation and irregular reworking of articular cartilage. Potential therapeutics for OA purpose at restoring correct chondrocyte functioning and inhibiting apoptosis. Earlier research have demonstrated that tauroursodeoxycholic acid (TUDCA) confirmed anti-inflammatory and anti-apoptotic exercise in lots of fashions of varied illnesses, appearing primarily by way of alleviation of endoplasmic reticulum (ER) stress. Nonetheless, little is thought about cytoprotective results of TUDCA on chondrocyte cells.
The current examine was designed to judge potential results of TUDCA on interleukin-1β (IL-1β) and tunicamycin (TNC)-stimulated NHAC-kn chondrocytes cultured in normoxic and hypoxic circumstances. Our outcomes confirmed that TUDCA alleviated ER stress in TNC-treated chondrocytes, as demonstrated by lowered CHOP expression; nonetheless, it was not efficient sufficient to stop apoptosis of NHAC-kn cells in both normoxia nor hypoxia.

NH2-PEG-COOH,500
33-HE005017-500
  • EUR 430.80
  • EUR 1170.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

N3-PEG-OH,500
33-HE006002-500
  • EUR 681.60
  • EUR 1923.60
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

N3-PEG-BIOTIN,500
33-HE006041-500
  • EUR 992.40
  • EUR 2856.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Biotin-PEG-COOH,500
33-HE041017-500
  • EUR 726.00
  • EUR 2056.80
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SH-PEG-SH,500
33-HO003003-500
  • EUR 310.80
  • EUR 812.40
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

AlKyne-PEG-AlKyne,500
33-HO007007-500
  • EUR 339.60
  • EUR 896.40
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

COOH-PEG-COOH,500
33-HO017017-500
  • EUR 200.40
  • EUR 478.80
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SC-PEG-SC,500
33-HO023023-500
  • EUR 200.40
  • EUR 478.80
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

MC Cellufine S-500
21-200-51 5 x 1 ml
EUR 286.8

MC Cellufine S-500
21-200-55 5 x 5 ml
EUR 504

MC Cellufine C-500
19-800-51 5 x 1 ml
EUR 260.4

MC Cellufine C-500
19-800-55 5 x 5 ml
EUR 414

MC Cellufine Q-500
19-907-51 5 x 1 ml
EUR 260.4

MC Cellufine Q-500
19-907-55 5 x 5 ml
EUR 414

Cellufine A-500
675980327 100 ml
EUR 388.8

Cellufine A-500
675980335 10 lt Ask for price

Cellufine A-500
19805 500 ml
EUR 631.2

Cellufine A-500
19806 5 lt Ask for price

MC Cellufine A-200
19-611-51 5 x 1 ml
EUR 260.4

MC Cellufine A-800
19-865-51 5 x 1 ml
EUR 260.4

MC Cellufine A-800
19-865-55 5 x 5 ml
EUR 414

5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]
A-1014
  • EUR 721.20
  • EUR 82.50
  • EUR 239.80
  • EUR 456.50
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

MC Cellufine MAX AminoButyl
21-500-15 1 x 5 ml
EUR 541.2

MC Cellufine MAX AminoButyl
21-500-51 5 x 1 ml
EUR 541.2

SH-PEG-NH2,500
33-HE003005-500
  • EUR 1909.20
  • EUR 681.60
  • 5g
  • g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

MAL-PEG-NH2,500
33-HE022005-500
  • EUR 622.80
  • EUR 1747.20
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

NH2-PEG-NH2,500
33-HO005005-500
  • EUR 282.00
  • EUR 726.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

N3-PEG-N3,500
33-HO006006-500
  • EUR 367.20
  • EUR 979.20
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

MC Cellufine MAX Q-r
20-500-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Q-r
20-500-55 5 x 5 ml
EUR 631.2

MC Cellufine Sulfate
19-845-15 1 x 5 ml
EUR 439.2

MC Cellufine Sulfate
19-845-51 5 x 1 ml
EUR 439.2

MC Cellufine Phosphate
195-15 1 x 5 ml
EUR 516

MC Cellufine Phosphate
195-51 5 x 1 ml
EUR 516

MC Cellufine PB
202-15 1 x 5 ml
EUR 542.4

MC Cellufine PB
202-51 5 x 1 ml
EUR 542.4

Cellufine Q-500
675982327 100 ml
EUR 439.2

Cellufine Q-500
675982335 10 lt Ask for price

Cellufine C-500
675983327 100 ml
EUR 388.8

Cellufine C-500
675983335 10 lt Ask for price

Cellufine S-500
21-200 100 ml
EUR 465.6

Cellufine S-500
21-201 500 ml
EUR 836.4

Cellufine S-500
21-202 5 lt Ask for price

Cellufine S-500
21-203 10 lt Ask for price

Cellufine C-500
19865 500 ml
EUR 631.2

Cellufine C-500
19866 5 lt Ask for price

Cellufine Q-500
19907 500 ml
EUR 861.6

Cellufine Q-500
19908 5 lt Ask for price

MC Cellufine MAX DEAE
21-000-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX DEAE
21-000-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX Butyl
21-100-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Butyl
21-100-55 5 x 5 ml
EUR 644.4

MC Cellufine MAX GS
21-300-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX GS
21-300-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX IB
21-600-15 1 x 5 ml
EUR 362.4

MC Cellufine MAX IB
21-600-51 5 x 1 ml
EUR 362.4

MC Cellufine SPA-HC
21-900-11 1 x 1 ml
EUR 446.4

MC Cellufine SPA-HC
21-900-15 1 x 5 ml
EUR 663.6

MC Cellufine SPA-HC
21-900-51 5 x 1 ml
EUR 663.6

MC Cellufine MAX Phenyl
20-700-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Phenyl
20-700-55 5 x 5 ml
EUR 644.4

MC Cellufine MAX CM
20-900 100 ml
EUR 458.4

MC Cellufine MAX CM
20-900-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX CM
20-900-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX CM
20-901 500 ml
EUR 1756.8

MC Cellufine MAX CM
20-902 5 lt Ask for price

MC Cellufine MAX CM
20-903 10 lt Ask for price

MC Cellufine Etclean L
200-15 1 x 5 ml
EUR 427.2

MC Cellufine Etclean L
200-51 5 x 1 ml
EUR 427.2

MC Cellufine GH-25
19-711-55 5 x 5 ml
EUR 516

MC Cellufine Etclean S
201-15 1 x 5 ml
EUR 427.2

MC Cellufine Etclean S
201-51 5 x 1 ml
EUR 427.2

MC Cellufine MAX DexS-Vir
21-800-15 1 x 5 ml
EUR 362.4

MC Cellufine MAX DexS-Vir
21-800-51 5 x 1 ml
EUR 362.4

MC Cellufine MAX S-r
20-300-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX S-h
20-400-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX S-h
20-400-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX Q-h
20-600-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Q-h
20-600-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX Phenyl LS
20-800-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Phenyl LS
20-800-55 5 x 5 ml
EUR 644.4

MC Cellufine MAX S-r
20300-55 5 x 5 ml
EUR 631.2

Cellufine A-800
673980327 100 ml
EUR 388.8

Cellufine A-800
673980335 10 lt Ask for price

Cellufine A-200
676-980-327 100 ml
EUR 388.8

Cellufine A-200
676980335 10 lt Ask for price

Cellufine A-200
19611 500 ml
EUR 631.2

Cellufine A-200
19612 5 lt Ask for price

Cellufine A-800
19800 500 ml
EUR 631.2

Cellufine A-800
19801 5 lt Ask for price

MBD1 Polyclonal Antibody
A-1006
  • EUR 740.34
  • EUR 117.70
  • EUR 306.90
  • EUR 462.00
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]
A-1018
  • EUR 702.06
  • EUR 82.50
  • EUR 239.80
  • EUR 443.30
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

PRDM4 Polyclonal Antibody
A-2004
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM5 Polyclonal Antibody
A-2005
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM10 Polyclonal Antibody
A-2010
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM11 Polyclonal Antibody
A-2011
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM13 Polyclonal Antibody
A-2013
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM16 Polyclonal Antibody
A-2016
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM17 Polyclonal Antibody
A-2017
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

EZH1 Polyclonal Antibody
A-2018
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

HSF1 Polyclonal Antibody
A-2401
  • EUR 905.64
  • EUR 235.40
  • EUR 423.50
  • EUR 574.20
  • 200 µl
  • 50 ul
  • 100 ul
  • 200 ul

PRMT3 Polyclonal Antibody
A-3003
  • EUR 740.34
  • Ask for price
  • Ask for price
  • EUR 462.00
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

SET1 Polyclonal Antibody
A-3011
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

SET07 Polyclonal Antibody
A-3013
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

LSD1 Polyclonal Antibody
A-3018
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

HDAC10 Polyclonal Antibody
A-4010
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PCAF Polyclonal Antibody
A-4012
  • EUR 740.34
  • EUR 117.70
  • EUR 306.90
  • EUR 462.00
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Histone H3K9ac (Acetyl H3K9) Polyclonal Antibody
A-4022
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K14ac (Acetyl H3K14) Polyclonal Antibody
A-4023
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K18ac (Acetyl H3K18) Polyclonal Antibody
A-4024
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K23ac (Acetyl H3K23) Polyclonal Antibody
A-4025
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 383.90
  • 50 µg
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K56ac (Acetyl H3K56) Polyclonal Antibody
A-4026
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me1 (H3K4 Monomethyl) Polyclonal Antibody
A-4031
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me2 (H3K4 Dimethyl) Polyclonal Antibody
A-4032
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 383.90
  • 50 µg
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me3 (H3K4 Trimethyl) Polyclonal Antibody
A-4033
  • EUR 555.90
  • EUR 177.10
  • EUR 342.10
  • EUR 479.60
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K9me1 (H3K9 Monomethyl) Polyclonal Antibody
A-4034
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody
A-4035
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K9me3 (H3K9 Trimethyl) Polyclonal Antibody
A-4036
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me1 (H3K27 Monomethyl) Polyclonal Antibody
A-4037
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me2 (H3K27 Dimethyl) Polyclonal Antibody
A-4038
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody
A-4039
  • EUR 555.90
  • EUR 177.10
  • EUR 342.10
  • EUR 479.60
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me1 (H3K36 Monomethyl) Polyclonal Antibody
A-4040
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me2 (H3K36 Dimethyl) Polyclonal Antibody
A-4041
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me3 (H3K36 Trimethyl) Polyclonal Antibody
A-4042
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me1 (H3K79 Monomethyl) Polyclonal Antibody
A-4043
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me2 (H3K79 Dimethyl) Polyclonal Antibody
A-4044
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me3 (H3K79 Trimethyl) Polyclonal Antibody
A-4045
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me1 (H4K20 Monomethyl) Polyclonal Antibody
A-4046
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me2 (H4K20 Dimethyl) Polyclonal Antibody
A-4047
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me3 (H4K20 Trimethyl) Polyclonal Antibody
A-4048
  • EUR 555.90
  • EUR 173.80
  • EUR 302.50
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27ac (Acetyl H3K27) Polyclonal Antibody
A-4708
  • EUR 813.42
  • EUR 173.80
  • EUR 299.20
  • EUR 510.40
  • 100 µl
  • 25 ul
  • 50 ul
  • 100 ul

CRISPR Cas9 Monoclonal Antibody [7A9]
A-9000
  • EUR 573.30
  • EUR 71.50
  • EUR 200.20
  • EUR 355.30
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

CRISPR/Cas9 (SaCas9) Monoclonal Antibody [6H4]
A-9001
  • EUR 559.38
  • EUR 70.40
  • EUR 192.50
  • EUR 338.80
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

CLIMP-63 Polyclonal Antibody
A-0701
  • EUR 754.26
  • EUR 290.40
  • EUR 470.80
  • 100 µl
  • 50 ul
  • 100 ul

DNMT3A Polyclonal Antibody
A-1003
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

DNMT3B Polyclonal Antibody
A-1004
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

DNMT3L Polyclonal Antibody
A-1005
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

MBD3 Polyclonal Antibody
A-1008
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

MGMT Polyclonal Antibody
A-1010
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

MeCP2 Polyclonal Antibody
A-1012
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

TET1 Polyclonal Antibody
A-1020
  • EUR 628.98
  • EUR 221.10
  • EUR 386.10
  • 100 µl
  • 50 ul
  • 100 ul

DNMT1 Polyclonal Antibody
A-1700
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

TET2 Polyclonal Antibody
A-1701
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

MBD2 Polyclonal Antibody
A-1713
  • EUR 736.86
  • EUR 281.60
  • EUR 459.80
  • 100 µl
  • 50 ul
  • 100 ul

PRDM2 Polyclonal Antibody
A-2002
  • Ask for price
  • EUR 117.70
  • EUR 284.90
  • 100 µg
  • 20 ul
  • 50 ul

PRDM3 Polyclonal Antibody
A-2003
  • EUR 754.26
  • EUR 284.90
  • EUR 470.80
  • 100 µl
  • 50 ul
  • 100 ul

PRDM6 Polyclonal Antibody
A-2006
  • EUR 754.26
  • EUR 284.90
  • EUR 470.80
  • 100 µl
  • 50 ul
  • 100 ul

PRDM12 Polyclonal Antibody
A-2012
  • EUR 754.26
  • EUR 284.90
  • EUR 383.90
  • 100 µg
  • 50 ul
  • 100 ul

PRDM14 Polyclonal Antibody
A-2014
  • EUR 754.26
  • EUR 284.90
  • EUR 470.80
  • 100 µl
  • 50 ul
  • 100 ul

EZH2 Polyclonal Antibody
A-2019
  • EUR 754.26
  • EUR 284.90
  • EUR 470.80
  • 100 µl
  • 50 ul
  • 100 ul

EED Polyclonal Antibody
A-2020
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

Swi2/SNF2 Polyclonal Antibody
A-2023
  • EUR 742.08
  • EUR 303.60
  • EUR 463.10
  • 100 µl
  • 50 ul
  • 100 ul

SNFa/BRM Polyclonal Antibody
A-2025
  • EUR 740.34
  • EUR 235.40
  • EUR 383.90
  • 100 µg
  • 50 ul
  • 100 ul

Ini1 Polyclonal Antibody
A-2026
  • EUR 740.34
  • EUR 235.40
  • EUR 383.90
  • 100 µg
  • 50 ul
  • 100 ul

RNA Polymerase II Monoclonal Antibody [CTD4H8]
A-2032
  • EUR 754.26
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 50 ug
  • 100 ug

CBX5 Polyclonal Antibody
A-2701
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

EGLN1 Polyclonal Antibody
A-2702
  • EUR 580.26
  • Ask for price
  • Ask for price
  • 100 µl
  • 50 ul
  • 100 ul

RBBP4 Polyclonal Antibody
A-2703
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SIN3A Polyclonal Antibody
A-2704
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

CTBP1 Polyclonal Antibody
A-2705
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

PADI4 Polyclonal Antibody
A-2706
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCA5 Polyclonal Antibody
A-2707
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

IDH1 Polyclonal Antibody
A-2708
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

CHD4 Polyclonal Antibody
A-2709
  • EUR 535.02
  • EUR 322.30
  • EUR 423.50
  • 50 µl
  • 50 ul
  • 100 ul

CHAF1A Polyclonal Antibody
A-2710
  • EUR 535.02
  • EUR 322.30
  • EUR 423.50
  • 50 µl
  • 50 ul
  • 100 ul

BRD7 Polyclonal Antibody
A-2712
  • EUR 535.02
  • EUR 328.90
  • EUR 432.30
  • 50 µl
  • 50 ul
  • 100 ul

UHRF1 Polyclonal Antibody
A-2714
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

UHRF2 Polyclonal Antibody
A-2715
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCE1 Polyclonal Antibody
A-2716
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

ACTL6A Polyclonal Antibody
A-2717
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

MPG Polyclonal Antibody
A-2718
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

HIF1AN Polyclonal Antibody
A-2719
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

RNF2 Polyclonal Antibody
A-2720
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

PCGF6 Polyclonal Antibody
A-2721
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCB1 Polyclonal Antibody
A-2722
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

ALKBH3 Polyclonal Antibody
A-2723
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

BBOX1 Polyclonal Antibody
A-2724
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

BTAF1 Polyclonal Antibody
A-2725
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

CXXC1 Polyclonal Antibody
A-2726
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

KDM4B Polyclonal Antibody
A-2727
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

HELLS Polyclonal Antibody
A-2728
  • EUR 742.08
  • EUR 303.60
  • EUR 463.10
  • 100 µl
  • 50 ul
  • 100 ul

ING3 Polyclonal Antibody
A-2729
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

ING4 Polyclonal Antibody
A-2730
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

PHC1 Polyclonal Antibody
A-2731
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCAD1 Polyclonal Antibody
A-2732
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

USP16 Polyclonal Antibody
A-2733
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCC1 Polyclonal Antibody
A-2734
  • EUR 742.08
  • EUR 303.60
  • EUR 463.10
  • 100 µl
  • 50 ul
  • 100 ul

ERCC6L Polyclonal Antibody
A-2735
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMYD5 Polyclonal Antibody
A-2736
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

ATF2 Polyclonal Antibody
A-2738
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

BMI1 Polyclonal Antibody
A-2739
  • EUR 869.10
  • Ask for price
  • Ask for price
  • 100 µl
  • 50 ul
  • 100 ul

CTBP2 Polyclonal Antibody
A-2740
  • EUR 869.10
  • EUR 322.30
  • EUR 548.90
  • 100 µl
  • 50 ul
  • 100 ul

CTCF Polyclonal Antibody
A-2741
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

MTA2 Polyclonal Antibody
A-2742
  • EUR 869.10
  • EUR 322.30
  • EUR 548.90
  • 100 µl
  • 50 ul
  • 100 ul

PMS1 Polyclonal Antibody
A-2744
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SFN Polyclonal Antibody
A-2745
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCA4 Polyclonal Antibody
A-2746
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul

SMARCAL1 Polyclonal Antibody
A-2747
  • EUR 869.10
  • Ask for price
  • Ask for price
  • 100 µl
  • 50 ul
  • 100 ul

SMARCC2 Polyclonal Antibody
A-2748
  • EUR 580.26
  • EUR 223.30
  • EUR 353.10
  • 100 µl
  • 50 ul
  • 100 ul
Nonetheless, co-treatment with TUDCA alleviated inflammatory response induced by IL-1β, as proven by down regulation of Il-1β, Il-6, Il-8 and Cox2, and elevated the expression of antioxidant enzyme Sod2. Moreover, TUDCA enhanced Col IIα expression in IL-1β- and TNC-stimulated cells, however solely in normoxic circumstances. Altogether, these outcomes counsel that though TUDCA could show chondoprotective potential in ER-stressed cells, additional analyses are nonetheless crucial to totally affirm its attainable advice as potential candidate in OA remedy.

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