Downregulation of IRAK3 by miR-33b-3p relieves chondrocyte inflammation and apoptosis in an in vitro osteoarthritis model

Interleukin-1 receptor-associated kinase-3 (IRAK3) has a particular position in regulating irritation. Nevertheless, the practical position of IRAK3 and regulatory mechanism underlying the pathogenesis of osteoarthritis (OA) stay unclear. Right here, we first discovered that IRAK3 was upregulated, whereas miR-33b-3p was downregulated within the cartilage of OA sufferers and IL-1β-induced CHON-001 cells.

IRAK3 was confirmed because the direct goal of miR-33b-3p and negatively regulated by miR-33b-3p. There was an inverse correlation between IRAK3 mRNA expression and miR-33b-3p expression in OA cartilage tissues. The in vitro practical experiments confirmed that miR-33b-3p overexpression precipitated a exceptional enhance in viability, a big lower in inflammatory mediators (IL-1β and TNF-α), and apoptosis in IL-1β-induced CHON-001 cells. Importantly, IRAK3 knockdown imitated, whereas overexpression reversed the results of miR-33b-3p on IL-1β-induced irritation and apoptosis in CHON-001 cells. Collectively, miR-33b-3p considerably alleviated IL-1β-induced irritation and apoptosis by downregulating IRAK3, which can function a promising goal for OA.

USP7 Inhibition Alleviates H ₂ O ₂-Induced Damage in Chondrocytes through Inhibiting NOX4/NLRP3 Pathway

Osteoarthritis (OA), the most typical type of arthritis, is a quite common joint illness that usually impacts middle-aged to aged folks. Nevertheless, present remedy choices for OA are predominantly palliative. Thus, understanding its pathological course of and exploring its potential therapeutic approaches are of nice significance. Rat chondrocytes have been remoted and uncovered to hydrogen peroxide (H₂O₂) to imitate OA. The consequences of H₂O₂ on ubiquitin-specific protease 7 (USP7) expression, reactive oxygen species (ROS) ranges, proliferation, inflammatory cytokine launch, and pyroptosis have been measured.

USP7 was knocked down (KD) or overexpressed to research the position of USP7 in OA. Co-immunoprecipitation (Co-IP) was used to check the interplay between USP7 and NAD(P)H oxidases (NOX)four in addition to NOX4 ubiquitination. NOX4 inhibitor was utilized to check the involvement of NOX4 in USP7-mediated OA improvement. USP7 inhibitor was given to OA animals to additional examine the position of USP7 in OA in vivo.

Furthermore, H₂O₂ remedy considerably elevated USP7 expression, enhanced ROS ranges, and inhibited proliferation in rat chondrocytes. The overexpression of USP7 enhanced pyroptosis, ROS manufacturing, interleukin (IL)-1β and IL-18 ranges, and the expression degree of NLRP3, GSDMD-N, energetic caspase-1, pro-caspase-1, matrix metalloproteinases (MMP) 1, and MMP13, which was abolished by ROS inhibition. The USP7 KD protected rat chondrocytes in opposition to H₂O₂-induced harm. Co-IP outcomes confirmed that USP7 interacted with NOX4, and USP7 KD enhanced NOX4 ubiquitinylation.

The inhibition of NOX4 blocked the pro-OA impact of USP7. Furthermore, the USP7 inhibitor given to OA animals suppressed OA in vivo. USP7 inhibited NOX4 ubiquitination for degradation which results in elevated ROS manufacturing. ROS subsequently prompts NLPR3 inflammasome, resulting in enhanced manufacturing of IL-1β and IL-18, GSDMD-N-dependent pyroptosis, and extracellular matrix reworking. Thus, UPS7 contributes to the development of OA through NOX4/ROS/NLPR3 axis.

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Goal for Rheumatoid Arthritis

Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H⁺-activated cation channel household. Rising proof has urged that ASIC1a performs a vital position within the pathogenesis of rheumatoid arthritis (RA). Particularly, ASIC1a might promote irritation, synovial hyperplasia, articular cartilage, and bone destruction; these result in the development of RA, a continual autoimmune illness characterised by continual synovial irritation and extra-articular lesions.

On this evaluation, we offered a quick overview of the molecular properties of ASIC1a, together with the essential organic traits, tissue and cell distribution, channel blocker, and elements influencing the expression and performance, and centered on the potential therapeutic targets of ASIC1a in RA and doable mechanisms of blocking ASIC1a to enhance RA signs, akin to regulation of apoptosis, autophagy, pyroptosis, and necroptosis of articular cartilage, and synovial irritation and invasion of fibroblast-like cells in synovial tissue.

Protecting Impact of Pyrroloquinoline Quinone on TNF-α-induced Mitochondrial Damage in Chondrocytes

Osteoarthritis (OA) is a degenerative illness characterised by matrix degradation and cell loss of life resulting in a gradual lack of articular cartilage integrity. As a bacterial synthesis of quinine, pyrroloquinoline quinone (PQQ) is a robust redox cofactor with a wide range of organic advantages, together with antioxidant, anti-inflammation-induced mitochondrial metabolism regulation.

This examine was designed to research the impact of PQQ on TNF-α-induced mitochondrial injury in chondrocytes. Chondrocytes remoted from C57BL/6 mice have been uncovered to TNF-α 50 ng/mL, TNF-α 50 ng/mL + PQQ 10 µmol/L for 24 h. Then, morphological examine, practical examine and mechanism examine have been taken. The outcomes revealed TNF-α-induced chondrocyte mitochondrion injury could possibly be lowered by utility of PQQ, evidenced by elevated variety of mitochondria, well-kept mtDNA integrity, preserved ATP degree, reestablished mitochondrial membrane potential, and prevented mitochondrial perform.

OF Medium
MED1664	Scientific Laboratory Supplies	500G	EUR 79.2

ENDO Basal Media
MED002	Neuromics	500 ml	EUR 248.4

Pericyte Basal Media
PGB002	Neuromics	475 ml	EUR 325.2

Astrocyte Basal Media
PGB004	Neuromics	500 ml	EUR 325.2

500mL Gracess Insect Basal Medi
13-200-CV	Scientific Laboratory Supplies	PK6	EUR 406.8

Gc Medium Base 500gm
228950	Scientific Laboratory Supplies	EACH	EUR 178.8

NBS Medium base 330mm
SHA1144	Scientific Laboratory Supplies	EACH	EUR 1510.8

Medium 199
C0012-01	Addexbio	RT 500 mL Bottle	EUR 126

FRIIS BASE Medium, Liquid
F2485-100	GenDepot	100ml	Ask for price

FRIIS BASE Medium, Liquid
F2485-500	GenDepot	500ml	Ask for price

DC MEDIUM
D04-117-10kg	Alphabiosciences	10 kg	EUR 1894.8

DC MEDIUM
D04-117-2kg	Alphabiosciences	2kg	EUR 458.4

DC MEDIUM
D04-117-500g	Alphabiosciences	500 g	EUR 168

A Medium
DJ1018	Bio Basic	100g	EUR 101.76

EC MEDIUM
E05-100-10kg	Alphabiosciences	10 kg	EUR 976.8

EC MEDIUM
E05-100-2Kg	Alphabiosciences	2 Kg	EUR 259.2

EC MEDIUM
E05-100-500g	Alphabiosciences	500 g	EUR 114

M9 Medium
SD7024	Bio Basic	250g	EUR 86.1

YM Medium
SD7031	Bio Basic	250g	EUR 84.54

HLP MEDIUM
H08-107-10kg	Alphabiosciences	10 kg	EUR 2733.6

HLP MEDIUM
H08-107-2Kg	Alphabiosciences	2 Kg	EUR 640.8

HLP MEDIUM
H08-107-500g	Alphabiosciences	500 g	EUR 218.4

M63 Medium
SD7033	Bio Basic	250g	EUR 86.1

SIM MEDIUM
S19-110-10kg	Alphabiosciences	10 kg	EUR 1225.2

SIM MEDIUM
S19-110-2kg	Alphabiosciences	2kg	EUR 313.2

SIM MEDIUM
S19-110-500g	Alphabiosciences	500 g	EUR 128.4

SOB MEDIUM
S19-124-10kg	Alphabiosciences	10 kg	EUR 1158

SOB MEDIUM
S19-124-2kg	Alphabiosciences	2kg	EUR 298.8

SOB MEDIUM
S19-124-500g	Alphabiosciences	500 g	EUR 124.8

Ec Medium 500gm
231430	Scientific Laboratory Supplies	EACH	EUR 176.4

TCBS Medium
MED1188	Scientific Laboratory Supplies	PK10	EUR 9.6

M9CA Medium
SD7025	Bio Basic	250g	EUR 86.1

Sob Medium 500gm
244310	Scientific Laboratory Supplies	EACH	EUR 261.6

DNase Medium
MED1196	Scientific Laboratory Supplies	PK10	EUR 10.8

TYGPN Medium
SD7032	Bio Basic	250g	EUR 84.01

NBS Innova 44 Medium Base 330mm
SHA1112	Scientific Laboratory Supplies	EACH	EUR 1566

Heller's Medium
CP014-010	GenDepot	10X1L	EUR 118.8

Heller's Medium
CP014-500	GenDepot	50L	EUR 151.2

anti-Activator of basal transcription 1
YF-PA18596	Abfrontier	50 ul	EUR 435.6
Description: Mouse polyclonal to Activator of basal transcription 1

anti-Activator of basal transcription 1
YF-PA18597	Abfrontier	50 ug	EUR 435.6
Description: Mouse polyclonal to Activator of basal transcription 1

anti-Activator of basal transcription 1
YF-PA18598	Abfrontier	50 ul	EUR 435.6
Description: Mouse polyclonal to Activator of basal transcription 1

anti-Activator of basal transcription 1
YF-PA18599	Abfrontier	50 ug	EUR 435.6
Description: Mouse polyclonal to Activator of basal transcription 1

Insect Cell Medium: TNM-FH Insect Culture Medium
ABP-MED-10001	Allele Biotech	1 liter	Ask for price

Mounting Medium
4300	Virostat	3 ml	EUR 216.6
Description: This is Mounting medium (non-fading) used for maintaining optimal conditions needed to obtain the maximum fluorescence emission from Fluorescein.

Advanced Medium
C0003-04	Addexbio	RT 500 mL Bottle	EUR 123.6

COLIFORM MEDIUM
C03-127-10kg	Alphabiosciences	10 kg	EUR 1588.8

COLIFORM MEDIUM
C03-127-2kg	Alphabiosciences	2kg	EUR 392.4

COLIFORM MEDIUM
C03-127-500g	Alphabiosciences	500 g	EUR 150

Hoagland's Medium
CP015-010	GenDepot	10X1L	EUR 118.8

Hoagland's Medium
CP015-500	GenDepot	50L	EUR 151.2

Insect Cell Medium: Serum-Free Insect Culture Medium
ABP-MED-10002	Allele Biotech	1 liter	Ask for price

RPMI 1640 Medium
abx098879-500ml	Abbexa	500 ml	EUR 210

A-1 MEDIUM
A01-116-10kg	Alphabiosciences	10 kg	EUR 1240.8

A-1 MEDIUM
A01-116-2Kg	Alphabiosciences	2 Kg	EUR 316.8

A-1 MEDIUM
A01-116-500g	Alphabiosciences	500 g	EUR 129.6

MCDB 131 Medium
CM034-050	GenDepot	500ml	EUR 102

MCDB 131 Medium
CM034-300	GenDepot	6x500ml	EUR 198

MCDB 131 Medium
CM034-310	GenDepot	10x500ml	EUR 262.8

MCDB 131 Medium
CM034-320	GenDepot	20x500ml	EUR 408

MCDB 131 Medium
CM034-350	GenDepot	50x500ml	EUR 702

Medium 199/BCDB 105
C0012-02	Addexbio	RT 500 mL Bottle	EUR 181.2

Insect Cell Medium: Grace?s Insect Medium (Unsupplemented)
ABP-MED-10004	Allele Biotech	1 liter	Ask for price

Isp Medium 2 500gm
277010	Scientific Laboratory Supplies	EACH	EUR 356.4

Isp Medium 4 500gm
277210	Scientific Laboratory Supplies	EACH	EUR 340.8

BPS Medium 1
79259	BPS Bioscience	100 ml	EUR 120
Description: This liquid BPS Medium is optimized for use with many BPS Reporter Kits including_x000D_ • 60612: AP1 Reporter Kit (JNK Pathway)_x000D_ • 60514: ARE Reporter Kit (Nrf2 Antioxidant Pathway)_x000D_ • 60611: CRE/CREB Reporter Kit (cAMP/PKA Signaling Pathway)_x000D_ • 60614: NF-κB Reporter Kit (NF-κB Signaling Pathway)_x000D_ • 60509: Notch1/CSL Reporter Kit (Notch Signaling Pathway)_x000D_ • 60654: SBE Reporter Kit (TGFβ/SMAD signaling pathway)_x000D_ • 60511: SRE Reporter Kit (MAPK/ERK Signaling Pathway)_x000D_ • 60500: TCF/LEF Reporter Kit (Wnt Signaling Pathway)

BPS Medium 7
79260	BPS Bioscience	100 ml	EUR 120
Description: This liquid BPS Medium is optimized for use with select BPS reporter kits.

BPS Medium 8
79385	BPS Bioscience	100 ml	EUR 120
Description: This liquid BPS Medium is optimized for use with the CSF1R/SRE Reporter Kit (BPS Bioscience, #79379).

Thaw Medium 8
79652-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines including NF- κB Reporter (Luc) – THP-1 Cell Line, #79645

Thaw Medium 8
79652-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines including NF- κB Reporter (Luc) – THP-1 Cell Line, #79645

Thaw Medium 9
79665-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including_x000D_• CRE/CREB Reporter Lentivirus #79580 _x000D_• NF-κB Reporter Luciferase Reporter Lentivirus #79564

Thaw Medium 9
79665-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, using • CRE/CREB Reporter Lentivirus #79580 _x000D_• NF-κB Reporter Luciferase Reporter Lentivirus #79564

Thaw Medium 10
79704-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid medium is optimized to culture select BPS Bioscience cell lines.

Thaw Medium 10
79704-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid medium is optimized to culture select BPS Bioscience cell lines.

Thaw Medium 11
79976-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid medium is optimized to culture select BPS Bioscience cell lines._x000D_Optimized for Use With:_x000D_NF- κB Reporter (Luc) - Raw 264.7 Cell line (BPS Bioscience 79978)

Thaw Medium 11
79976-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid medium is optimized to culture select BPS Bioscience cell lines._x000D_Optimized for Use With:_x000D_NF- κB Reporter (Luc) - Raw 264.7 Cell line (BPS Bioscience 79978)

Thaw Medium 12
78074-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines, including: • Cas9-expressing MDA-MB-231 cells (BPS Bioscience #78069)

Thaw Medium 12
78074-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines, including: • Cas9-expressing MDA-MB-231 cells (BPS Bioscience #78069)

Thaw Medium 14
78397-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines.

Thaw Medium 14
78397-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines.

Thaw Medium 15
78412-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines.

Thaw Medium 15
78412-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines.

Thaw Medium 16
78647-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for use with tetracycline-inducible system.

Thaw Medium 16
78647-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for use with tetracycline-inducible system.

Thaw Medium 4
60181-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• CFTR - HEK 293 Recombinant Cell Line #60506• Nav1.8/β2 - HEK293 Recombinant Cell Line #60521• NaV1.7-HEK293 Recombinant Cell Line #60607

Thaw Medium 4
60181-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• CFTR - HEK 293 Recombinant Cell Line #60506• Nav1.8/β2 - HEK293 Recombinant Cell Line #60521• NaV1.7-HEK293 Recombinant Cell Line #60607

Thaw Medium 5
60182-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• Gli Reporter - NIH3T3 Recombinant Cell line (Hedgehog Pathway) #60409

Thaw Medium 5
60182-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• Gli Reporter - NIH3T3 Recombinant Cell line (Hedgehog Pathway) #60409

Thaw Medium 6
60183-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• Myc Reporter (Luc) - HCT116 Recombinant Cell Line (Myc Signaling Pathway) #60520• NF-κB Reporter (Luc) - HCT116 Recombinant Cell Line #60623 • RARα Reporter - HEK293 Recombinant Cell Line #60503 • RARβ Reporter - HEK293 Recombinant Cell Line #60603 • RARγ Reporter - HEK293 Reporter Cell Line #60604

Thaw Medium 6
60183-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• Myc Reporter (Luc) - HCT116 Recombinant Cell Line (Myc Signaling Pathway) #60520• NF-κB Reporter (Luc) - HCT116 Recombinant Cell Line #60623 • RARα Reporter - HEK293 Recombinant Cell Line #60503 • RARβ Reporter - HEK293 Recombinant Cell Line #60603 • RARγ Reporter - HEK293 Reporter Cell Line #60604

Thaw Medium 2
60184-1	BPS Bioscience	100 ml	EUR 150
Description: This liquid Cell Thawing Medium is optimized for thawing and plating BPS Bioscience's Jurkat-based cell lines, including• PD-1/NFAT Reporter-Jurkat cell #60535• NFAT Reporter (Luc) - Jurkat Cell Line #60621• NF-κB-Luciferase Reporter (Luc) - Jurkat Cell Line #60651• ADCC Bioassay Effector Cell F variant (Low Affinity) #60540• ADCC Bioassay Effector Cell V variant (High Affinity) #60541Note: once cells are well-established, switch to the appropriate cell growth medium.

Thaw Medium 2
60184-2	BPS Bioscience	500 ml	EUR 675
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including_x000D__x000D_• PD-1/NFAT Reporter-Jurkat cell #60535_x000D__x000D_• NFAT Reporter (Luc) - Jurkat Cell Line #60621_x000D__x000D_• NF-ĸB-Luciferase Reporter (Luc) - Jurkat Cell Line #60651_x000D__x000D_• ADCC Bioassay Effector Cell F variant (Low Affinity) #60540_x000D__x000D_• ADCC Bioassay Effector Cell V variant (High Affinity) #60541_x000D__x000D_Note: once cells are well-established, switch to the appropriate cell growth medium.

Thaw Medium 7
60185-1	BPS Bioscience	100 ml	EUR 140
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including• Myc Reporter (Luc) - HCT116 Recombinant Cell Line (Myc Signaling Pathway) #60520 • NF-κB Reporter (Luc) - HCT116 Recombinant Cell Line #60623

Thaw Medium 7
60185-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines, including • Myc Reporter (Luc) - HCT116 Recombinant Cell Line (Myc Signaling Pathway) #60520 • NF-κB Reporter (Luc) - HCT116 Recombinant Cell Line #60623

Thaw Medium 3
60186-1	BPS Bioscience	100 ml	EUR 150
Description: This liquid Cell Thaw Medium is optimized for thawing and plating BPS Bioscience's CHO cell-based recombinant cell lines, including• TCR Activator - CHO Recombinant Cell line #60539 • TCR activator / PD-L1 - CHO Recombinant Cell line #60536 It is designed for use in a 37°C incubator with an atmosphere of 5% CO2/95% air. Note: once cells are well established, switch to an appropriate cell growth medium.

Thaw Medium 3
60186-2	BPS Bioscience	500 ml	EUR 645
Description: This liquid thaw medium is optimized for thawing and plating select BPS Bioscience recombinant cell lines, including_x000D__x000D_• TCR Activator - CHO Recombinant Cell line #60539 _x000D_• TCR activator / PD-L1 - CHO Recombinant Cell line #60536 _x000D__x000D_• CD27 CHO-K1 Stable Recombiant Cell Line #60624 _x000D__x000D_• PD-L1 - CHO Recombinant Cell Line #60543 _x000D__x000D_• NF-κB Reporter (Luc) - CHO-K1 Recombinant Cell Line #60622_x000D_• CD137L (4-1BBL) CHO-K1 Recombinant Cell Line #60523_x000D__x000D_It is designed for use in a 37°C incubator with an atmosphere of 5% CO2/95% air. _x000D_Note: once cells are well established, switch to an appropriate cell growth medium._x000D_

Thaw Medium 1
60187-1	BPS Bioscience	100 ml	EUR 155
Description: This liquid HEK293 Cell Thawing Medium is optimized for thawing and plating BPS Bioscience's HEK293 recombinant cell lines.

Thaw Medium 1
60187-2	BPS Bioscience	500 ml	EUR 695
Description: This liquid Thaw Medium is optimized for thawing and plating BPS Bioscience's HEK293 recombinant cell lines.

10mL S.O.C. Medium
46-003-CR	Scientific Laboratory Supplies	PK10	EUR 122.4

Medium 199 (Mod) Powder
90-050PB	Scientific Laboratory Supplies	EACH	EUR 93.48

Assay Medium 1B
79617-1	BPS Bioscience	100 ml	EUR 135
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• TGF/SMAD Signaling Pathway SBE Reporter - HEK293 Cell Line #60653 _x000D_• AP-1 Reporter - HEK293 Recombinant Cell Line (JNK signaling pathway) #60405

Assay Medium 1B
79617-2	BPS Bioscience	500 ml	EUR 675
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• TGF/SMAD Signaling Pathway SBE Reporter - HEK293 Cell Line #60653 _x000D_• AP-1 Reporter - HEK293 Recombinant Cell Line (JNK signaling pathway) #60405

Assay Medium 2B
79619-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• Foxp3 Reporter (Luc) - Jurkat Recombinant Cell Line -#60628

Assay Medium 2B
79619-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• Foxp3 Reporter (Luc) - Jurkat Recombinant Cell Line -#60628

Assay Medium 5A
79620-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience cell lines.

Assay Medium 5A
79620-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience cell lines.

Assay Medium 2A
79621-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• ADCC Bioassay Effector Cell F variant (Low Affinity) - Jurkat Recombinant Cell Line #60540 _x000D_• ADCC Bioassay Effector Cell V variant (High Affinity) - Jurkat Recombinant Cell Line #60541

Assay Medium 2A
79621-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• ADCC Bioassay Effector Cell F variant (Low Affinity) - Jurkat Recombinant Cell Line #60540 _x000D_• ADCC Bioassay Effector Cell V variant (High Affinity) - Jurkat Recombinant Cell Line #60541

Assay Medium 2C
79623-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• TIGIT / NFAT Reporter - Jurkat Recombinant Cell Line - #60538_x000D_• CD155/TCR Activator - CHO Recombinant Cell Line -#60548

Assay Medium 2C
79623-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including:_x000D_• TIGIT / NFAT Reporter - Jurkat Recombinant Cell Line, #60538 • CD155/TCR Activator - CHO Recombinant Cell Line, #60548

Assay Medium 7B
79718-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience cell lines._x000D_Optimized for use with Myc Reporter (Luc) - HCT116 Recombinant Cell Line (Myc Signaling Pathway), #60520

Assay Medium 7B
79718-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid assay medium is optimized for use in cellular assays in select BPS Bioscience cell lines._x000D_Optimized for use with Myc Reporter (Luc) - HCT116 Recombinant Cell Line (Myc Signaling Pathway), #60520

Assay Medium 1A
79805-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including TrkA / SRE Reporter - HEK293 Recombinant Cell Line (#79798)

Assay Medium 1A
79805-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Assay Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including TrkA / SRE Reporter - HEK293 Recombinant Cell Line (#79798)

Assay Medium 2C
78544-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Assay Medium 2C
78544-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Assay Medium 7A
78673-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid Assay Medium is optimized for use with BPS Bioscience cell-based assay

Assay Medium 7A
78673-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Assay Medium is optimized for use with BPS Bioscience cell-based assay

Assay Medium 1C
78674-1	BPS Bioscience	100 ml	EUR 120
Description: This liquid Assay Medium is optimized for use with BPS Bioscience cell-based assay.

Assay Medium 1C
78674-2	BPS Bioscience	500 ml	EUR 600
Description: This liquid Assay Medium is optimized for use with BPS Bioscience cell-based assay.

H Medium Broth
DJ1019	Bio Basic	100g	EUR 73.06

NeuroProgenitor Medium
NM42400	Neuromics	125 ml	EUR 364.8

Growth Medium 1A
79528	BPS Bioscience	500 ml	EUR 715
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 3B
79529	BPS Bioscience	500 ml	EUR 715
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 2B
79530	BPS Bioscience	500 ml	EUR 700
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol._x000D_Optimized for use with:_x000D_IL-2 Jurkat Luciferase Reporter - Jurkat Cell Line #60481 NF-kB Luciferase Reporter - Jurkat Cell Line #60651 Foxp3 Reporter (Luc) - Jurkat Recombinant Cell Line #60628

Growth Medium 1B
79531	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 1C
79532	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 1K
79533	BPS Bioscience	500 ml	EUR 715
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 5A
79534	BPS Bioscience	500 ml	EUR 715
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 4A
79535	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 1D
79536	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 3C
79537	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 1E
79538	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 3D
79539	BPS Bioscience	500 ml	EUR 735
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 1F
79540	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 5B
79541	BPS Bioscience	500 ml	EUR 685
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 6A
79542	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 7A
79543	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 1G
79544	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Optimized for use with GR-GAL4 Reporter (Luc) -HEK293 Recombinant Cell Line (Glucocorticoid Receptor Pathway), #60655, and CD137/NF-κB Reporter - HEK293 Recombinant Cell Line, #79289

Growth Medium 7B
79545	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_Optimized for use with Myc Reporter (Luc) - HCT116 Recombinant Cell Line, #60520.

Growth Medium 1H
79546	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.Optimized for Use With: T-Rex HEK293 Recombinant Cell Line (BPS Bioscience, #71227)

Growth Medium 1J
79552	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 3E
79553	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 4B
79554	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including: • Nav1.8/β2 - HEK293 Recombinant Cell Line #60521

Growth Medium 1L
79555	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 2C
79592	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol._x000D_Optimized for use with:_x000D_ GITR/NF-κB Luciferase Reporter (Luc) - Jurkat Cell Line #60546_x000D_

Growth Medium 4C
79631	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including: • CFTR - HEK 293 Recombinant Cell Line - #60506

Growth Medium 2E
79638	BPS Bioscience	500 ml	EUR 715
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol._x000D_Optimized for use with:_x000D_CRE/CREB Reporter (Luc) - Jurkat Cell Line - #79636_x000D_

Growth Medium 2D
79639	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.Optimized for Use With: TCR Activator - Raji Cell Line (BPS Bioscience, #60556)

Growth Medium 8A
79653	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol._x000D_Optimized for Use With: _x000D_NF- κB Reporter (Luc) - THP-1 Cell Line - #79645

Growth Medium 6B
79657	BPS Bioscience	500 ml	EUR 700
Description: This liquid Growth Medium is optimized for use in cellular assays in select BPS Bioscience's cell lines, including: • NF-kB Reporter (Luc) - A549 Stable Cell Line #60625

Growth Medium 2F
79669	BPS Bioscience	500 ml	EUR 685
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol._x000D_ Optimized for use with ICOS NFAT - Jurkat Cell Line, #79668

Growth Medium 1M
79723	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol._x000D_ Optimized for Use With: CSF1R / SRE - Reporter HEK293 Recombinant Cell Line (#79380)

Growth Medium 2G
79734	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_Optimized for use with: ADCC Bioassay Effector Cell - Mouse - Jurkat Recombinant Cell Line, (BPS #79733)

Growth Medium 2H
79784	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_ Optimized for use with: Anti-BCMA CAR Jurkat/NFAT (Luciferase) Reporter Cell Line (BPS #79694)

Growth Medium 1N
79801	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. Follow the culturing instructions on the designated protocol.

Growth Medium 2J
79812	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_ Optimized for use with: LAG3 / IL-2 Reporter - Jurkat Recombinant Cell Line (BPS# 79813)

Growth Medium 3F
79829	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_Optimized for Use With: BCMA / GLuc - CHO Recombinant Cell Line #79830

Growth Medium 3G
79882	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines and lentivirus._x000D_Optimized for Use with_x000D_ FcGRIIIA (CD16a) Lentivirus, FcER1G Lentivirus

Growth Medium 3J
79974	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_Optimized for use with: ACE2 - CHO Recombinant Cell Line (BPS Bioscience #79959)

Growth Medium 3K
78041	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. _x000D_Optimized for Use With_x000D_ CD19 / BCMA / Firefly Luciferase - CHO Recombinant Cell Line (BPS Bioscience, #78030)

Growth Medium 7C
78076	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell pools_x000D_Optimized for use With: Cas9-expressing HCT116 cell pool (BPS Bioscience, #78073)

Growth Medium 6C
78077	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell pools._x000D_Optimized for use with: Cas9-expressing A549 cell pool (BPS Bioscience, #78072)

Growth Medium 2K
78078	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell pools._x000D_Optimized for use with: Cas9-expressing Jurkat cell pool (BPS Bioscience, #78070) Cas9-expressing Raji cell pool (BPS Bioscience, #78071)

Growth Medium 2L
78094	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell pools._x000D_Optimized for Use With: CRISPRa (SAM) Jurkat Cell Pool (BPS Bioscience, #78080)

Growth Medium 1P
78095	BPS Bioscience	500 ml	EUR 685
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines._x000D_Optimized for Use With:_x000D_ TMPRSS2 - Vero E6 Recombinant Cell Line (BPS Bioscience, #78081)

Growth Medium 1Q
78096	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell pools_x000D_Optimized for Use With:_x000D_ Cas9-Expressing Neuro2A Cell Pool (BPS Bioscience, #78087)

Growth Medium 3L
78104	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 1R
78180	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell pools.Optimized for Use With: Cas9-Expressing MCF7 Cell Pool (BPS Bioscience #78179)

Growth Medium 2M
78181	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 2N
78196	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 7D
78200	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines

Growth Medium 1S
78221	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.Optimized for Use With: CRISPRa (SAM) HeLa Cell Line (BPS Bioscience, #78193), CRISPRa (SAM) HepG2 Cell Line (BPS Bioscience, #78194)

Growth Medium 6D
78222	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.Optimized for Use With: CRISPRa (SAM) HEK293 Cell Line (BPS Bioscience, #78192)

Growth Medium 2P
78354	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 3M
78377	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 1T
78379	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 2Q
78380	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 6E
78385	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 2R
78411	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 2S
78430	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 3N
78534	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 6F
78540	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 1U
78548	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines

Growth Medium 1V
78551	BPS Bioscience	500 ml	EUR 650
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines.

Growth Medium 3A
60188	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select CHO and CHO-K1 cell lines.

Growth Medium 2A
60190	BPS Bioscience	500 ml	EUR 755
Description: This liquid Growth Medium is a complete medium optimized to culture select Jurkat cell lines.

The current work strongly means that the mitochondrion is a vital goal for OA chondrocyte injury induced by TNF-α and the PQQ safety from this injury ameliorates mitochondrial dysfunction induced by TNF-α. PQQ may be a possible chemical for OA intervention.