Downregulation of IRAK3 by miR-33b-3p relieves chondrocyte inflammation and apoptosis in an in vitro osteoarthritis model

Interleukin-1 receptor-associated kinase-3 (IRAK3) has a particular position in regulating irritation. Nevertheless, the practical position of IRAK3 and regulatory mechanism underlying the pathogenesis of osteoarthritis (OA) stay unclear. Right here, we first discovered that IRAK3 was upregulated, whereas miR-33b-3p was downregulated within the cartilage of OA sufferers and IL-1β-induced CHON-001 cells.

IRAK3 was confirmed because the direct goal of miR-33b-3p and negatively regulated by miR-33b-3p. There was an inverse correlation between IRAK3 mRNA expression and miR-33b-3p expression in OA cartilage tissues. The in vitro practical experiments confirmed that miR-33b-3p overexpression precipitated a exceptional enhance in viability, a big lower in inflammatory mediators (IL-1β and TNF-α), and apoptosis in IL-1β-induced CHON-001 cells. Importantly, IRAK3 knockdown imitated, whereas overexpression reversed the results of miR-33b-3p on IL-1β-induced irritation and apoptosis in CHON-001 cells. Collectively, miR-33b-3p considerably alleviated IL-1β-induced irritation and apoptosis by downregulating IRAK3, which can function a promising goal for OA.

USP7 Inhibition Alleviates H 2 O 2-Induced Damage in Chondrocytes through Inhibiting NOX4/NLRP3 Pathway

Osteoarthritis (OA), the most typical type of arthritis, is a quite common joint illness that usually impacts middle-aged to aged folks. Nevertheless, present remedy choices for OA are predominantly palliative. Thus, understanding its pathological course of and exploring its potential therapeutic approaches are of nice significance. Rat chondrocytes have been remoted and uncovered to hydrogen peroxide (H2O2) to imitate OA. The consequences of H2O2 on ubiquitin-specific protease 7 (USP7) expression, reactive oxygen species (ROS) ranges, proliferation, inflammatory cytokine launch, and pyroptosis have been measured.

USP7 was knocked down (KD) or overexpressed to research the position of USP7 in OA. Co-immunoprecipitation (Co-IP) was used to check the interplay between USP7 and NAD(P)H oxidases (NOX)four in addition to NOX4 ubiquitination. NOX4 inhibitor was utilized to check the involvement of NOX4 in USP7-mediated OA improvement. USP7 inhibitor was given to OA animals to additional examine the position of USP7 in OA in vivo.

Furthermore, H2O2 remedy considerably elevated USP7 expression, enhanced ROS ranges, and inhibited proliferation in rat chondrocytes. The overexpression of USP7 enhanced pyroptosis, ROS manufacturing, interleukin (IL)-1β and IL-18 ranges, and the expression degree of NLRP3, GSDMD-N, energetic caspase-1, pro-caspase-1, matrix metalloproteinases (MMP) 1, and MMP13, which was abolished by ROS inhibition. The USP7 KD protected rat chondrocytes in opposition to H2O2-induced harm. Co-IP outcomes confirmed that USP7 interacted with NOX4, and USP7 KD enhanced NOX4 ubiquitinylation.

The inhibition of NOX4 blocked the pro-OA impact of USP7. Furthermore, the USP7 inhibitor given to OA animals suppressed OA in vivo. USP7 inhibited NOX4 ubiquitination for degradation which results in elevated ROS manufacturing. ROS subsequently prompts NLPR3 inflammasome, resulting in enhanced manufacturing of IL-1β and IL-18, GSDMD-N-dependent pyroptosis, and extracellular matrix reworking. Thus, UPS7 contributes to the development of OA through NOX4/ROS/NLPR3 axis.

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Goal for Rheumatoid Arthritis

Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel household. Rising proof has urged that ASIC1a performs a vital position within the pathogenesis of rheumatoid arthritis (RA). Particularly, ASIC1a might promote irritation, synovial hyperplasia, articular cartilage, and bone destruction; these result in the development of RA, a continual autoimmune illness characterised by continual synovial irritation and extra-articular lesions.

On this evaluation, we offered a quick overview of the molecular properties of ASIC1a, together with the essential organic traits, tissue and cell distribution, channel blocker, and elements influencing the expression and performance, and centered on the potential therapeutic targets of ASIC1a in RA and doable mechanisms of blocking ASIC1a to enhance RA signs, akin to regulation of apoptosis, autophagy, pyroptosis, and necroptosis of articular cartilage, and synovial irritation and invasion of fibroblast-like cells in synovial tissue.

Downregulation of IRAK3 by miR-33b-3p relieves chondrocyte inflammation and apoptosis in an in vitro osteoarthritis model

Protecting Impact of Pyrroloquinoline Quinone on TNF-α-induced Mitochondrial Damage in Chondrocytes

Osteoarthritis (OA) is a degenerative illness characterised by matrix degradation and cell loss of life resulting in a gradual lack of articular cartilage integrity. As a bacterial synthesis of quinine, pyrroloquinoline quinone (PQQ) is a robust redox cofactor with a wide range of organic advantages, together with antioxidant, anti-inflammation-induced mitochondrial metabolism regulation.

This examine was designed to research the impact of PQQ on TNF-α-induced mitochondrial injury in chondrocytes. Chondrocytes remoted from C57BL/6 mice have been uncovered to TNF-α 50 ng/mL, TNF-α 50 ng/mL + PQQ 10 µmol/L for 24 h. Then, morphological examine, practical examine and mechanism examine have been taken. The outcomes revealed TNF-α-induced chondrocyte mitochondrion injury could possibly be lowered by utility of PQQ, evidenced by elevated variety of mitochondria, well-kept mtDNA integrity, preserved ATP degree, reestablished mitochondrial membrane potential, and prevented mitochondrial perform.

BME 100X Vitamins for Basal Medium Eagle (Modified)
BML01-100ML 100 ml
EUR 73
  • Product line: Animal Cell Culture Media
  • Product family: Basal Medium Eagle
Description: 100X Vitamins for Basal Medium Eagle (Modified)

BME 100X Vitamins for Basal Medium Eagle (Modified)
BML01-500ML 500 ml
EUR 92
  • Product line: Animal Cell Culture Media
  • Product family: Basal Medium Eagle
Description: 100X Vitamins for Basal Medium Eagle (Modified)

anti-Activator of basal transcription 1
YF-PA18596 50 ul
EUR 363
Description: Mouse polyclonal to Activator of basal transcription 1

anti-Activator of basal transcription 1
YF-PA18597 50 ug
EUR 363
Description: Mouse polyclonal to Activator of basal transcription 1

anti-Activator of basal transcription 1
YF-PA18598 50 ul
EUR 363
Description: Mouse polyclonal to Activator of basal transcription 1

anti-Activator of basal transcription 1
YF-PA18599 50 ug
EUR 363
Description: Mouse polyclonal to Activator of basal transcription 1

Activator of Basal Transcription 1 (ABT1) Antibody
20-abx110789
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Activator of Basal Transcription 1 (ABT1) Antibody
abx037021-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Activator of Basal Transcription 1 (ABT1) Antibody
20-abx004524
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Activator Of Basal Transcription 1 (ABT1) Antibody
20-abx338734
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Activator of Basal Transcription 1 (ABT1) Antibody
abx230056-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Activator Of Basal Transcription 1 (ABT1) Antibody (HRP)
20-abx334566
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Activator Of Basal Transcription 1 (ABT1) Antibody (FITC)
20-abx334567
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Activator Of Basal Transcription 1 (ABT1) Antibody (Biotin)
20-abx334568
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Goat Activator of basal transcription 1(ABT1) ELISA kit
E06A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Goat Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activator of basal transcription 1(ABT1) ELISA kit
E06A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Goat Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activator of basal transcription 1(ABT1) ELISA kit
E06A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Goat Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activator of basal transcription 1(ABT1) ELISA kit
E02A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rat Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activator of basal transcription 1(ABT1) ELISA kit
E02A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rat Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activator of basal transcription 1(ABT1) ELISA kit
E02A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rat Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activator of basal transcription 1(ABT1) ELISA kit
E03A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activator of basal transcription 1(ABT1) ELISA kit
E03A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activator of basal transcription 1(ABT1) ELISA kit
E03A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activator of basal transcription 1(ABT1) ELISA kit
E04A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activator of basal transcription 1(ABT1) ELISA kit
E04A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activator of basal transcription 1(ABT1) ELISA kit
E04A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activator of basal transcription 1(ABT1) ELISA kit
E01A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activator of basal transcription 1(ABT1) ELISA kit
E01A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activator of basal transcription 1(ABT1) ELISA kit
E01A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activator of basal transcription 1(ABT1) ELISA kit
E08A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Canine Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activator of basal transcription 1(ABT1) ELISA kit
E08A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Canine Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activator of basal transcription 1(ABT1) ELISA kit
E08A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Canine Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activator of basal transcription 1(ABT1) ELISA kit
E07A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Porcine Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activator of basal transcription 1(ABT1) ELISA kit
E07A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Porcine Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activator of basal transcription 1(ABT1) ELISA kit
E07A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Porcine Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activator of basal transcription 1(ABT1) ELISA kit
E09A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Monkey Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activator of basal transcription 1(ABT1) ELISA kit
E09A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Monkey Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activator of basal transcription 1(ABT1) ELISA kit
E09A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Monkey Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bovine Activator of basal transcription 1, ABT1 ELISA KIT
ELI-24538b 96 Tests
EUR 928

Mouse Activator of basal transcription 1, Abt1 ELISA KIT
ELI-24666m 96 Tests
EUR 865

Human Activator of basal transcription 1, ABT1 ELISA KIT
ELI-24776h 96 Tests
EUR 824

Human Activator Of Basal Transcription 1 (ABT1) ELISA Kit
abx385562-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

BME 100X Amino Acids for Basal Medium Eagle (Modified). W/O L-glutamine.
BML02-500ML 500 ml
EUR 104
  • Product line: Animal Cell Culture Media
  • Product family: Basal Medium Eagle
Description: 100X Amino Acids for Basal Medium Eagle (Modified). Without L-glutamine.

Guinea pig Activator of basal transcription 1(ABT1) ELISA kit
E05A1165-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activator of basal transcription 1(ABT1) ELISA kit
E05A1165-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Guinea pig Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activator of basal transcription 1(ABT1) ELISA kit
E05A1165-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Activator of basal transcription 1(ABT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anderson's Basal Salt
CP001-010 10x1L
EUR 99

Anderson's Basal Salt
CP001-500 50L
EUR 126

Anderson's Basal Salt
CP002-010 10X1L
EUR 99

Anderson's Basal Salt
CP002-500 50L
EUR 126

Pericyte Basal Media
PGB002 475 ml
EUR 271

Astrocyte Basal Media
PGB004 500 ml
EUR 271

ENDO Basal Media
MED002 500 ml
EUR 207

500 ML GRACES'S INSECT BASAL MEDIUM (VAUGHN MOD.) WITH L-GLUTAMINE, WITHOUT INSECT HEMOLYMPH
13-200-CV 500 mL/pk
EUR 315
Description: Specialty Media; Insect Media Products

Advanced Medium
C0003-04 RT 500 mL Bottle
EUR 103

Medium 199
C0012-01 RT 500 mL Bottle
EUR 105

COLIFORM MEDIUM
C03-127-10kg 10 kg
EUR 1324

COLIFORM MEDIUM
C03-127-2kg 2kg
EUR 327

COLIFORM MEDIUM
C03-127-500g 500 g
EUR 125

EC MEDIUM
E05-100-10kg 10 kg
EUR 814

EC MEDIUM
E05-100-2Kg 2 Kg
EUR 216

EC MEDIUM
E05-100-500g 500 g
EUR 95

HLP MEDIUM
H08-107-10kg 10 kg
EUR 2278

HLP MEDIUM
H08-107-2Kg 2 Kg
EUR 534

HLP MEDIUM
H08-107-500g 500 g
EUR 182

VALI Medium
450 500 ml
EUR 265

Mounting Medium
4300 3 ml
EUR 180.5
Description: This is Mounting medium (non-fading) used for maintaining optimal conditions needed to obtain the maximum fluorescence emission from Fluorescein.

BEGM Medium
451 500 ml
EUR 152

DC MEDIUM
D04-117-10kg 10 kg
EUR 1579

DC MEDIUM
D04-117-2kg 2kg
EUR 382

DC MEDIUM
D04-117-500g 500 g
EUR 140

Heller's Medium
CP014-010 10X1L
EUR 99

Heller's Medium
CP014-500 50L
EUR 126

Hoagland's Medium
CP015-010 10X1L
EUR 99

Hoagland's Medium
CP015-500 50L
EUR 126

NeuroProgenitor Medium
NM42400 125 ml
EUR 304

SIM MEDIUM
S19-110-10kg 10 kg
EUR 1021

SIM MEDIUM
S19-110-2kg 2kg
EUR 261

SIM MEDIUM
S19-110-500g 500 g
EUR 107

SOB MEDIUM
S19-124-10kg 10 kg
EUR 965

SOB MEDIUM
S19-124-2kg 2kg
EUR 249

SOB MEDIUM
S19-124-500g 500 g
EUR 104

M9 Medium
SD7024 250g
EUR 71.75
  • Product category: Culture Media/Medium

M9CA Medium
SD7025 250g
EUR 71.75
  • Product category: Culture Media/Medium

YM Medium
SD7031 250g
EUR 70.45
  • Product category: Culture Media/Medium

TYGPN Medium
SD7032 250g
EUR 70.01
  • Product category: Culture Media/Medium

M63 Medium
SD7033 250g
EUR 71.75
  • Product category: Culture Media/Medium

A Medium
DJ1018 100g
EUR 84.8
  • Product category: Culture Media/Medium

Basal Body Marker antibody
10-2480 250 ug
EUR 492
Description: Mouse monoclonal Basal Body Marker antibody

Basal Cell Cytokeratin antibody
10R-7959 100 ug
EUR 370
Description: Mouse monoclonal Basal Cell Cytokeratin antibody

ExpressMax™ Basal Salts
145 500 g
EUR 86

DKW Basal Salt Mixture
CP007-010 10X1L
EUR 99

DKW Basal Salt Mixture
CP007-500 50L
EUR 126

Cancer of the breast, basal-like breast carcinoma, 48 cases (1.5mm), set 1
BRC965 1
EUR 410
Description: Breast cancer tissue array, basal-like breast carcinoma, 48 cases (1.5mm), set 1, 96 cores, 48 cases, containing 35 cases basal-like, 3 cases luminal A, 3 cases luminal B, 4 cases Her2 overexpression types and 1 case Adenoid cystic carcinoma for positive control, with grading, TNM staging, and ER, PR, HER2, P53, EGFR, Ki67,CK5/6 and Nestin IHC data.

Insect Cell Medium: TNM-FH Insect Culture Medium
ABP-MED-10001 1 liter Ask for price
    • Product line: Cell Culture Reagents
    • Brand:

Insect Cell Medium: Serum-Free Insect Culture Medium
ABP-MED-10002 1 liter Ask for price
    • Product line: Cell Culture Reagents
    • Brand:

Insect Cell Medium: Grace?s Insect Medium (Unsupplemented)
ABP-MED-10004 1 liter Ask for price
    • Product line: Cell Culture Reagents
    • Brand:

Aqueous Mounting Medium
AR1018 10mL X5 (Enough for 800-1200 assays)
EUR 80

Antifade Mounting Medium
AR1109 10mL (for 1000 assays)
EUR 65

AddexBio Cryopreservation Medium
C0002-20mL RT vial
EUR 104

CARY & BLAIR MEDIUM
C03-131-10kg 10 kg
EUR 2185

CARY & BLAIR MEDIUM
C03-131-2Kg 2 Kg
EUR 514

CARY & BLAIR MEDIUM
C03-131-500g 500 g
EUR 176

EC MEDIUM, MODIFIED
E05-108-10kg 10 kg
EUR 858

EC MEDIUM, MODIFIED
E05-108-2Kg 2 Kg
EUR 226

EC MEDIUM, MODIFIED
E05-108-500g 500 g
EUR 98

Hepatocyte Maintenance Medium
HM42600 100 ml
EUR 409

Neuron Growth Medium
HNM001 500 ml
EUR 331

Agarose, medium EEO
GE4750-100G 100 g
EUR 166

Agarose, medium EEO
GE4750-500G 500 g
EUR 429

FLUID THIOGLYCOLLATE MEDIUM
F06-101-10kg 10 kg
EUR 792

FLUID THIOGLYCOLLATE MEDIUM
F06-101-2kg 2kg
EUR 211

FLUID THIOGLYCOLLATE MEDIUM
F06-101-500g 500 g
EUR 94

FluoreGuard Mounting Medium
FMM030 30 ml
EUR 96

FluoreGuard Mounting Medium
FMM060 60 ml
EUR 116

FluoreGuard Mounting Medium
FMM500 500 ml
EUR 327

FluoreGuard Mounting Medium
FMM999 1000 ml
EUR 530

RPMI 1640 Medium
abx098879-500ml 500 ml
EUR 175
  • Shipped within 5-10 working days.

A-1 MEDIUM
A01-116-10kg 10 kg
EUR 1034

A-1 MEDIUM
A01-116-2Kg 2 Kg
EUR 264

A-1 MEDIUM
A01-116-500g 500 g
EUR 108

SuperMOUNT? Mounting Medium
1211-20
EUR 201

Recovery Medium - 6x12mL
1711 4/PK
EUR 128

EverBrite Mounting Medium
23001 10mL
EUR 178
Description: Minimum order quantity: 1 unit of 10mL

MCDB 131 Medium
CM034-050 500ml
EUR 85

MCDB 131 Medium
CM034-300 6x500ml
EUR 165

MCDB 131 Medium
CM034-310 10x500ml
EUR 219

MCDB 131 Medium
CM034-320 20x500ml
EUR 340

MCDB 131 Medium
CM034-350 50x500ml
EUR 585

Williams' Medium E
CM063-050 500ml
EUR 91

Williams' Medium E
CM063-300 6x500ml
EUR 266

Williams' Medium E
CM063-310 10x500ml
EUR 313

Williams' Medium E
CM063-320 20x500ml
EUR 604

Williams' Medium E
CM063-350 50x500ml
EUR 975

Cereal Crops Medium
CP003-005 5L
EUR 113

Cereal Crops Medium
CP003-010 10X1L
EUR 169

Kao Michayluk Medium
CP017-010 10X1L
EUR 99

Kao Michayluk Medium
CP017-500 50L
EUR 126

Orchid Maintenance Medium
CP037-010 10X1L
EUR 109

Orchid Maintenance Medium
CP037-500 50L
EUR 138

Woody Plants Medium
CP040-010 10X1L
EUR 101

Woody Plants Medium
CP040-500 50L
EUR 126

MOTILITY TEST MEDIUM
M13-121-10kg 10 kg
EUR 1528

MOTILITY TEST MEDIUM
M13-121-2Kg 2 Kg
EUR 371

MOTILITY TEST MEDIUM
M13-121-500g 500 g
EUR 137

Sepadextran-25 Medium
SD25M-100 100 g
EUR 271

Sepadextran-25 Medium
SD25M-500 500 g
EUR 1036

Sepadextran-50 Medium
SD50M-100 100 g
EUR 344

Sepadextran-50 Medium
SD50M-500 500 g
EUR 1285

REINFORCED CLOSTRIDIUM MEDIUM
R18-105-10kg 10 kg
EUR 1194

REINFORCED CLOSTRIDIUM MEDIUM
R18-105-2kg 2kg
EUR 299

REINFORCED CLOSTRIDIUM MEDIUM
R18-105-500g 500 g
EUR 118

Schwann Growth Medium
SGM001 500 ml
EUR 244

TERRIFIC BROTH MEDIUM
T20-114-10kg 10 kg
EUR 675

TERRIFIC BROTH MEDIUM
T20-114-2kg 2kg
EUR 186

TERRIFIC BROTH MEDIUM
T20-114-500g 500 g
EUR 87

THIOGLYCOLLATE MEDIUM, BREWER
T20-118-10kg 10 kg
EUR 1364

THIOGLYCOLLATE MEDIUM, BREWER
T20-118-2kg 2kg
EUR 336

THIOGLYCOLLATE MEDIUM, BREWER
T20-118-500g 500 g
EUR 128

2XYT MICROBIAL MEDIUM
X24-102-10kg 10 kg
EUR 614

2XYT MICROBIAL MEDIUM
X24-102-2Kg 2 Kg
EUR 173

2XYT MICROBIAL MEDIUM
X24-102-500g 500 g
EUR 83

H Medium Broth
DJ1019 100g
EUR 60.88
  • Product category: Culture Media/Broth

Basal Cell Adhesion Molecule/CD239
PR27244 2 ug
EUR 191

Anti-Basal cell Cytokeratin antibody
STJ16100229 100 µg
EUR 447

Human Cartilage Growth Medium PrimaCell: Normal Articular Cartilage Growth Medium
9-46043 5 x 100 ml Ask for price

Rat Cartilage Growth Medium PrimaCell: Normal Articular Cartilage Growth Medium
9-25023 5 x 100 ml Ask for price

Basal Cell Adhesion Molecule (BCAM) Antibody
20-abx129079
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Basal Cell Adhesion Molecule (BCAM) Antibody
20-abx327530
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Basal Cell Adhesion Molecule (BCAM) Antibody
20-abx339595
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Basal Cell Adhesion Molecule (BCAM) Antibody
20-abx333957
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Basal Cell Adhesion Molecule (BCAM) Antibody
20-abx213158
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Basal Cell Adhesion Molecule (BCAM) Antibody
20-abx171384
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug
  • Please enquire.

Recombinant Basal Cell Adhesion Molecule (BCAM)
4-RPB716Hu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P50895
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 28.7kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Basal Cell Adhesion Molecule expressed in: E.coli

Alpha-glia Expansion Medium
AGEM-001 500 ml
EUR 375

Formulated RPMI-1640 Medium
C0004-01 RT 500 mL Bottle
EUR 98

Optimized RPMI-1640 Medium
C0004-02 RT 500 mL Bottle
EUR 100

Leibovitz's L-15 Medium
C0006-01 RT 500 mL Bottle
EUR 108

Stellate Cell Medium/kit
C0009-01 RT 500 mL Bottle
EUR 227

Cervical Epithalial cell medium
C0011-01 RT 500 mL Bottle
EUR 239

Medium 199/BCDB 105
C0012-02 RT 500 mL Bottle
EUR 151

EC MEDIUM WITH MUG
E05-101-10kg 10 kg
EUR 2351

EC MEDIUM WITH MUG
E05-101-2kg 2kg
EUR 550

EC MEDIUM WITH MUG
E05-101-500g 500 g
EUR 186

Human Epithelial Cell Medium
ECM001 500 mL
EUR 323

Fluorguard Antifade Mounting Medium
F001 1 ml
EUR 86

The current work strongly means that the mitochondrion is a vital goal for OA chondrocyte injury induced by TNF-α and the PQQ safety from this injury ameliorates mitochondrial dysfunction induced by TNF-α. PQQ may be a possible chemical for OA intervention.

 

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